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TranscriptomicsMassive redeployment of PRC1 proteins suppresses tumor formation during Drosophila development
Polycomb group proteins form two main complexes, PRC2 and PRC1, which generally coregulate their target genes. Here, we show that PRC1 components act as neoplastic tumor suppressors independently of PRC2 function. By mapping the distribution of PRC1 components and the histone H3K27me3 mark, we ident...
ORGANISM(S): Drosophila melanogaster 
2016-07-18 | E-GEOD-74080 | biostudies-arrayexpress
TranscriptomicsRNA-Seq characterization of human H1-derived NPC differentiation timecourse
High resolution transcriptional profiling of H1-derived human neuronal precursor cells over a timecourse of differentiation in vitro. Human NPC differentiation timecourse covers Days 0,1,2,4,5,11, and 18 after induction of neuronal differentiation as described in manuscript. Each time point was assa...
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-56785 | biostudies-arrayexpress
TranscriptomicsRNA-Seq characterization of select lincRNA knockout mouse models
It has become clear that long intergenic noncoding RNAs (lincRNAs) are an important layer of genome regulation. Thousands have been identified in mammals, yet only a few have been tested through genetic ablation in animal models. Of the few that have, many yields weak to unobservable phenotypes, rai...
ORGANISM(S): Mus musculus 
2013-11-30 | E-GEOD-49581 | biostudies-arrayexpress
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