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TranscriptomicsExpression data from osteocytes in virgin,lactating and post lactation mice
We have previously shown that during lactation, osteocytes directly remodel their perilacunar and pericanalicular matrix, thereby mobilizing calcium and contributing to maternal bone loss. To identify genes potentially responsible for perilacunar remodeling, microarray analysis was performed on oste...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-23496 | biostudies-arrayexpress
TranscriptomicsIntegrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways
Osteocytes, positioned within bone’s interstitial space, are subject to fluid flow upon whole bone loading. Such fluid flow is widely theorized to be a mechanical signal transduced by osteocytes, initiating a poorly understood cascade of signaling events mediating bone metabolism. The objective ...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-42874 | biostudies-arrayexpress
TranscriptomicsRNA-seq Analysis of Mineralizing IDG-SW3 Cultures with Mature Osteocyte Characteristics
We differentiated the murine IDG-SW3 cell line for 28 days until the cells displayed a mature osteocyte-like phenotype. Triplicate cultures of the IDG-SW3 cells were then treated with 50nM PTH (1-34) or vehicle control (PBS) for 24 hours. RNA was harvested from the cultures and used to perform RNA S...
ORGANISM(S): Mus musculus 
2015-03-03 | E-GEOD-61351 | biostudies-arrayexpress
TranscriptomicsOsteoblast and Osteocyte Profiles at Different Cell-cummunication Status
Type of Experiment: 1) Profiles of Osteoblast vs. osteocyte in vitro; 2) Profiles of osteoblast low density vs. confluency in vitro; 3) Profiles of osteocyte with gap junction vs. without gap junction. Experimental factors: 1) 2T3 osteoblast cells at low density expressed extensive filopodia, remin...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-2234 | biostudies-arrayexpress
TranscriptomicsTranscriptomic comparison of osteocyte cell lines – determining their utility as models to study sex hormone regulation of skeletal function
Comparions of transcriptomes of two osteocyte cell lines under conditions that increase and decrease androgens. To study gene expression differences and the cell lines' appropriateness for studying androgen regulation of skeletal function
ORGANISM(S): Mus musculus 
2026-09-01 | E-MTAB-16564 | biostudies-arrayexpress
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