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GenomicsSox4 is a key oncogenic target in C/EBPa mutant Acute Myeloid Leukemia
Mutation or epigenetic silencing of the transcription factor C/EBPa is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but down-stream targets relevant for leukemogenesis are not known. Here we identify Sox4 as a dir...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-50565 | biostudies-arrayexpress
TranscriptomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2013-02-11 | E-GEOD-39662 | biostudies-arrayexpress
TranscriptomicsSox4 is a key oncogenic target in C/EBP? mutant Acute Myeloid Leukemia
Mutation or epigenetic silencing of the transcription factor C/EBP? is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but down-stream targets relevant for leukemogenesis are not known. Here we identify Sox4 as a dir...
ORGANISM(S): Mus musculus 
2013-03-23 | E-GEOD-45430 | biostudies-arrayexpress
UnknownEpigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible.
Not available
S-EPMC524389 | biostudies-literature
UnknownC/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia.
Not available
S-EPMC5812331 | biostudies-literature
UnknownThe mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction.
Not available
S-EPMC1409732 | biostudies-literature
UnknownC/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis.
Not available
S-EPMC4618662 | biostudies-literature
UnknownSox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.
Not available
S-EPMC4038627 | biostudies-literature
GenomicsRUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
Cell fate decisions during hematopoiesis are governed by lineage-specific transcription factors, such as RUNX1, SCL/TAL1, FLI1 and C/EBP family members. In order to gain insight about how these transcription factors regulate the activation of hematopoietic genes during embryonic development, we meas...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40235 | biostudies-arrayexpress
UnknownRUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction.
Not available
S-EPMC6899442 | biostudies-literature
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