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GenomicsPromoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain
Precise control of gene expression plays fundamental roles in brain development, but the roles of chromatin regulators in neuronal connectivity have remained poorly understood. Here, we find that depletion of the nucleosome remodeling and deacetylation (NuRD) complex in the cerebellar cortex by in v...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-57758 | biostudies-arrayexpress
GenomicsChromatin Remodeling Inactivates Activity Genes and Regulates Neural Coding
Activity-dependent transcription influences neuronal connectivity, but the roles and mechanisms of inactivation of activity-dependent genes have remained poorly understood. Genome-wide analyses in the mouse cerebellum revealed that the nucleosome remodeling and deacetylase (NuRD) complex deposits th...
ORGANISM(S): Mus musculus 
2016-07-18 | E-GEOD-83253 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E47 targets in the neuroblastoma cell line SK-N-SH at 8 hours and 20 hours
E47 is a basic Helix Loop Helix (bHLH) transcription factor that has important roles in cell fate determination and differentiation of many cell types. In the nervous system E47 heterodimerizes with tissue-specific, pro-neural bHLH transcription factors and activates downstream target genes. To iden...
ORGANISM(S): Homo sapiens 
2006-02-01 | E-MEXP-413 | biostudies-arrayexpress
TranscriptomicsEGFRvIII/STAT3 targets in glioblastoma pathogenesis
Next generation sequencing platforms were used to identify STAT3 targets in the background of EGFRvIII expresssion mRNA of 3 EGFRvIII positive brain tumor stem cell lines (BTSC #68, 73, and 90) were compared to an EGFRvIII negative line (#41) to identify EGFRvIII-regulated targets in human BTSC. EGF...
ORGANISM(S): Mus musculus 
2016-04-13 | E-GEOD-51281 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse neocortex to investigate age-related gene expression changes
Aging is associated with major nuclear changes affecting genomic integrity and gene expression. Here we compare the gene expression profiles in the neocortex of young (5 months old) and old (30 months old) B6xC3 F1 mice. In a related study, we compare genes that change expression with age to SIRT1 a...
ORGANISM(S): Mus musculus 
2009-01-13 | E-GEOD-13120 | biostudies-arrayexpress
UnknownPHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS
Not available
S-SCDT-10_1038-S44319-024-00082-0 | biostudies-other
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