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TranscriptomicsReorganization of the host epigenome by a viral oncogene
Adenovirus small e1a causes ~70% reduction in cellular levels of histone H3 lysine 18 acetylation (H3K18ac). It is unclear, however, where this dramatic reduction occurs genome-wide. ChIP-seq revealed that e1a erases 95% of H3K18ac peaks in normal fibroblasts and replaces them with one-third as many...
ORGANISM(S): Homo sapiens 
2012-04-04 | E-GEOD-32340 | biostudies-arrayexpress
GenomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (Mnase-Seq)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-02 | E-GEOD-66907 | biostudies-arrayexpress
GenomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (ChIP-Seq yeast)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-02 | E-GEOD-66909 | biostudies-arrayexpress
GenomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (ChIP-Seq mouse)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-66910 | biostudies-arrayexpress
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