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ProteomicsThe yeast AIF homolog Nde1 integrates metabolic and proteostatic signals on the mitochondrial surface and executes cell death
Little is known about the proteolytic turnover of mitochondrial proteins under static growth conditions. Combining dynamic isotope labeling and mass spectrometry in yeast cells, we found an exceptionally high turnover for the NADH dehydrogenase Nde1. This homolog of the mammalian apoptosis inducing ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-06 | PXD012531 | Pride
Mitochondria Protein turnover Nde1 Yeast Apoptosis 
ProteomicsMitoprotein-induced stress launches a global transcriptional fail-safe program
Most mitochondrial proteins are synthesized as cytosolic precursor proteins before being imported into mitochondria. Cytosolic accumulation of mitochondrial precursors hazards cellular fitness and is associated with a growing number of diseases, but is not observed under physiological conditions. In...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-01-14 | PXD011789 | Pride
Mitochondria Chaperones Protein import Yeast Proteasome Oxidative phosphorylation Stress response 
UnknownIncreased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol
Not available
S-SCDT-EMBOJ-2021-107913 | biostudies-other
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