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TranscriptomicsPhevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression
Staphylococcus aureus produces the cyclic dipeptides tyrvalin and phevalin (aureusimine A and B, respectively). A previous study reported that S. aureus mutants not capable of producing these compounds were less virulent in vivo through the deranged regulation of virulence factor genes. These findin...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-32920 | biostudies-arrayexpress
ProteomicsHDX-MS of AcrIF9 and AcrIF2 binding to CRISPR IF Csy complex
CRISPR RNA-guided detection and degradation of foreign DNA is a dynamic process. Viruses can interfere with this cellular defense by expressing small proteins called anti-CRISPRs. While structural models of anti-CRISPRs bound to their target complex provide static snapshots that inform mechanism, th...
ORGANISM(S): Pseudomonas aeruginosa N002 
2022-11-01 | PXD036446 | Pride
Csy Hdx Acr 
MetabolomicsGut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase co...
2022-12-06 | MTBLS5138 | MetaboLights
ProteomicsBeyond Repression: ArsR Functions as a Global Activator of Metabolic and Redox Responses in Escherichia Coli
The arsenic-responsive repressor, ArsR, has long been understood as a canonical regulator of the arsRBC operon, which confers resistance to arsenic stress. However, recent studies suggest a broader regulatory scope for ArsR. Here, we investigated the proteomic landscape of Escherichia coli strains w...
ORGANISM(S): Escherichia coli 
2026-02-02 | PXD071635 | Pride
Mass spectrometry based proteomic analysis Arsenic stress response Ars operon expression Arsr regulation Escherichia coli proteome Proteome stress response Differential proteome analysis Proteomic pathway analysis 
ProteomicsBarley flag leaf LC-MS/MS - Proteomic comparison of near-isogenic barley (Hordeum vulgare L
Senescence is the last developmental phase of plant tissues, plant organs and, in the case of monocarpic senescence, entire plants. In monocarpic crops such as barley, it leads to massive remobilization of nitrogen (primarily from degradation of photosynthetic proteins) and other nutrients to develo...
ORGANISM(S): Hordeum vulgare (Barley) 
2017-02-08 | PXD002307 | Pride
Barley Flag leaf Senescence Lc-ms/ms 
TranscriptomicsTranscriptome analysis of infection of the archaeon Sulfolobus solfataricus with STIV
Time series of infection of Sulfolobus solfataricus strain 2-2-12 cells infected with STIV are compared with uninfected cells over 32 h. Two-condition experiment, Control vs. Infected cells sampled at 5 time points (0, 8, 16, 24, 32 h post infection). Biological replicates: 3 control, 3 infected, pa...
ORGANISM(S): Sulfolobus solfataricus 
2008-07-25 | E-GEOD-12235 | biostudies-arrayexpress
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