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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
MetabolomicsComparative non-targeted LC-MS metabolomic profiling of murine bone marrow-derived macrophages cultured in 2D versus 3D

Macrophages are key drivers of inflammatory and fibrotic diseases and their activation is shaped by interactions in their tissue microenvironment. However, dissecting the processes that drive immunopathology has proved challenging as traditional 2D culture methods fail to capture the complex mole...

2026-06-08 | MTBLS12917 | MetaboLights
MetabolomicsInnate Immune Training of Human Macrophages by Cathelicidin Analogs
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection by the chicken cathelicidin-2 analog DCATH-2. Thus...
2022-07-11 | MTBLS4495 | MetaboLights
TranscriptomicsProfiling microRNA expression in bovine alveolar macrophages using RNA-seq
In this study, we determined the miRNA expression profile of bovine alveolar macrophages, using next-generation sequencing strategy. On an Illumina HiSeq 2000 machine, we sequenced 8 miRNA libraries, prepared from small RNA fractions of alveolar macrophages isolated from 8 different healthy animals ...
ORGANISM(S): Bos taurus 
2013-09-09 | E-GEOD-41138 | biostudies-arrayexpress
MetabolomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights
TranscriptomicsChanges in transcription patterns in BoMac cells in response to PDD spirochetes
Papillomatous digital dermatitis (PDD) is a polymicrobial infection in soft tissue adjacent to the hoof and is the leading cause of lameness in dairy cattle. Treponema phagedenis-like (TPL) spirochetes are a constant feature of PDD lesions and are localized deep in infected tissue. Host-cell respon...
ORGANISM(S): Bos taurus 
2007-06-22 | E-GEOD-6702 | biostudies-arrayexpress
TranscriptomicsEarly response of bovine alveolar macrophages to infection with live and heat-killed Mycobacterium bovis
Bovine tuberculosis, caused by Mycobacterium bovis, is a disease of considerable economic importance yet comparatively little is known about the bovine immune response to the disease. Alveolar macrophages are one of the first cells to encounter mycobacteria following infection. In this experiment we...
ORGANISM(S): Bos taurus 
2010-01-30 | E-GEOD-19237 | biostudies-arrayexpress
TranscriptomicsNorwegian Red (NRF) cattle macrophage challenge1
In vitro challenge of bovine macrophages (derived from blood monocytes)with live bacteria of a Staphylococcus aureus strain isolated from a clinical mastitis case.
ORGANISM(S): Bos taurus 
2012-01-01 | E-TABM-1133 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bovine macrophages and dendritic cells infected with live and heat-inactivated Salmonella
The Affymetrix bovine global microarray was used to examine the transcriptional response of Holstein-derived macrophages and dendritic cells infected with heat-inactivated Salmonella (n=6), live Salmonella (n=6) and uninfected controls (n=6) during early infection (2 hours)
ORGANISM(S): Bos taurus 
2010-12-18 | E-TABM-878 | biostudies-arrayexpress
TranscriptomicsmicroRNA profile of bovine monocyte-derived macrophages infected in vitro with Streptococcus agalactiae
In a subclinical infection such as bovine streptococcal mastitis, early recognition is a great challenge, and miRNAs profiling could potentially assist in the diagnosis and contribute to the understanding of pathogenicity and defense mechanisms. We have examined the miRNA repertoire during the early...
ORGANISM(S): Bos taurus 
2018-02-28 | E-MTAB-5937 | biostudies-arrayexpress
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