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TranscriptomicsSmall RNA sequencing in normal and psoriatic skin
We report the application of Illumina small RNA sequencing to normal human skin, as well as uninvolved and involved psoriatic skin. By obtaining over 600 million qualified reads from 20 healthy controls and 47 psoriasis biopsies (uninvolved/involved), we have generated a complete small RNA profile i...
ORGANISM(S): Homo sapiens 
2011-08-19 | E-GEOD-31037 | biostudies-arrayexpress
TranscriptomicsGlobal methylation analysis of psoriatic (involved and uninvolved) and control skin
Psoriasis is a chronic inflammatory immune-mediated disorder affecting the skin and other organs including joints. Over 1,300 transcripts are altered in psoriatic involved skin compared to normal skin. Global epigenetic profiles of psoriatic skin have not been described. Here we describe the first g...
ORGANISM(S): Homo sapiens 
2011-11-11 | E-GEOD-31835 | biostudies-arrayexpress
TranscriptomicsGlobal expression analysis of BAP1 knockdown in transfected 92.1 cells
Analysis of the effect that reduced BAP1 levels have on global gene expression.The hypothesis tested was that reduction in BAP1 levels would produce changes in gene expression similar to changes observed in class 2 uveal melanomas. Data provided insight into genes that are disrupted with reduced BAP...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-24896 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of skin from patients with atopic dermatitis before and after treatment with narrow-band UVB radiation
Background: Atopic dermatitis (AD) is a common inflammatory skin disease exhibiting a predominantly Th2/"T22" immune activation and a defective epidermal barrier. Narrow-band UVB (NB-UVB) is considered an efficient treatment for moderate to severe AD. In psoriasis, NB-UVB has been found to suppress ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-27887 | biostudies-arrayexpress
GenomicCollaborative Association Study of Psoriasis

The goal of this collaborative study is to combine the resources and expertise of three groups with long-standing studies of psoriasis genetics in order to identify new genetic susceptibility factors for psoriasis, a common inflammatory skin disease that affects over 4 million Americans.

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phs000019 | dbGaP
TranscriptomicsPSORS2 is due to mutations in CARD14
Psoriasis is a common, immune-mediated, genetic disorder of the skin associated with arthritis in approximately 30% of cases. Previously, we localized PSORS2 (psoriasis susceptibility locus 2) to chromosome 17q25.3-qter following a genome-wide linkage scan in a family of European origin with multipl...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-36387 | biostudies-arrayexpress
TranscriptomicsRare and common variants in CARD14, an epidermal regulator of NF-kappaB, in psoriasis
Psoriasis is a common inflammatory disorder of the skin and other organs. We have determined that mutations in CARD14, encoding an NF-kB activator within skin epidermis, account for PSORS2. Here we describe fifteen additional rare, missense variants in CARD14, their distribution in seven psoriasis c...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-36381 | biostudies-arrayexpress
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