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UnknownTargeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria.
Not available
S-EPMC2715447 | biostudies-literature
TranscriptomicsPRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation (RNA-Seq)
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation, an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs ...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-53506 | biostudies-arrayexpress
GenomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [ChIP-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embryonic stem cells (ESCs). Divergent regions in H2AZ are likely key for its functional specialization, but we know little about how these differences contribute to chro...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40063 | biostudies-arrayexpress
GenomicsPRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-53508 | biostudies-arrayexpress
GenomicsH2A.Z.1 mono-ubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs [ChIP-seq]
Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in ESCs to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigate the function of H2A.Z.1 mono-ubiquitylation (H2A.Z.1ub) by mutation of the PRC1 ...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-53206 | biostudies-arrayexpress
GenomicsPRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation (ChIP-Seq)
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation, an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs ...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-53505 | biostudies-arrayexpress
UnknownStructural basis for PI(4)P-specific membrane recruitment of the Legionella pneumophila effector DrrA/SidM.
Not available
S-EPMC3974903 | biostudies-literature
UnknownEfficacy of Desvenlafaxine 50 mg/d Versus Placebo in the Long-Term Treatment of Major Depressive Disorder: A Randomized, Double-Blind Trial.
Not available
S-EPMC4664561 | biostudies-literature
UnknownThe neuropeptide substance P regulates aldosterone secretion in human adrenals.
Not available
S-EPMC7260184 | biostudies-literature
GenomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40065 | biostudies-arrayexpress
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