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TranscriptomicsDoxycycline alters metabolism and proliferation of human cell lines
The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of tetracyclines on mammalian cells -- including inhibition of the mitochondrial ribosome -- there have been few reports on potential off-target effects a...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-45029 | biostudies-arrayexpress
TranscriptomicsNovel dedifferentiated liposarcoma xenograft models reveal PTEN down regulation as a malignant signature and response to PI3K pathway inhibition
Liposarcoma is a type of soft tissue sarcoma, exhibiting poor survival and a high recurrence rate. Treatment is generally limited to surgery and radiation, emphasizing the need to understand this disease. Because very few in vivo and in vitro models can reproducibly recapitulate the human disease,...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42975 | biostudies-arrayexpress
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