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TranscriptomicsThe Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3). Suz12 is essential for PRC2 activity and its inactivation r...
ORGANISM(S): Mus musculus 
2011-08-11 | E-GEOD-31354 | biostudies-arrayexpress
TranscriptomicsHelin M.musculus Identification of genes repressed by CBX8 and BMI1
The polycomb group proteins form large repressive complexes. It has recently become evident, via ChIP on chip analysis, that the polycomb complexes, PRC1 and PRC2, target a large number of genes (Boyer et al., 2006; Bracken et al., 2006; Tolhuis et al., 2006), which are involved in cell fate decisio...
ORGANISM(S): Mus musculus 
2007-03-05 | E-MEXP-793 | biostudies-arrayexpress
UnknownThe polycomb group protein Suz12 is required for embryonic stem cell differentiation.
Not available
S-EPMC1899991 | biostudies-literature
GenomicsGenome-wide mapping of H3K4me3 and of PHF8 and ZNF711 binding sites in SH-SY5Y cells
We analyzed the genome wide binding sites for the potential XLMR genes PHF8 and ZNF711 in the neuroblastoma cell line SH-SY5Y using antibodies specific for PHF8 and ZNF711 and correlated this with binding pattern of H3K4me3. The total number of peaks detected for PHF8 based on 9.8 million sequence...
ORGANISM(S): Homo sapiens 
2010-03-08 | E-GEOD-20673 | biostudies-arrayexpress
GenomicsPolycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
The Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin in order to confer transcriptional silencing during lineage transitions remains unclear. Here...
ORGANISM(S): Mus musculus 
2012-11-17 | E-GEOD-41609 | biostudies-arrayexpress
TranscriptomicsMdm2 enhances stemness-promoting chromatin modifications through the Polycomb Repressor Complex 2 in a p53-Independent Manner [HCT116 microarray]
The Mdm2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that Mdm2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryonic fibroblasts, in the absence of p53. Similarly, Mdm2 depletion in ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-73294 | biostudies-arrayexpress
UnknownPeptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach.
Not available
S-EPMC310177 | biostudies-literature
UnknownCross-species oncogenomics offers insight into human muscle-invasive bladder cancer.
Not available
S-EPMC10464500 | biostudies-literature
UnknownPhysician-Led Synchronous Telemedicine Compared to Face-To-Face Care in Primary Care: A Systematic Review.
Not available
S-EPMC12274557 | biostudies-literature
UnknownCurrarino-Silverman syndrome: diagnosis and treatment of rare chest wall deformity, a case series.
Not available
S-EPMC8182498 | biostudies-literature
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