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GenomicsAutozygosity pilot Born in Bradford
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAS00001000462 | EGA
GenomicsA Novel HDAC Complex in the Control of Transcription and Genome Stability
The acetylation state of histones, controlled by histone acetyltransferases and deacetylases, profoundly affects DNA transcription and repair by modulating chromatin accessibility to the cellular machinery. The Schizosaccharomyces pombe HDAC Clr6 (human HDAC1) binds to different sets of proteins tha...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-10 | E-GEOD-57040 | biostudies-arrayexpress
GenomicsProgram specificity for Ptf1a in PancreasM-BM- versusM-BM- Neural Tube DevelopmentM-BM- correlates with distinctM-BM- collaborating cofactors and chromatin accessibility
Ptf1a is a lineage-specific basic-helix-loop-helix transcription factor critical in the development of both the pancreas and nervous system. How one transcription factor controls diverse programs of gene expression is a fundamental question in developmental biology. To uncover molecular strategies f...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-47459 | biostudies-arrayexpress
ProteomicsZebrafish 24hpf whole embryo MZezh2mutant
Polycomb group (PcG) proteins are transcriptional repressors important to maintain cell identity during embryonic development. Ezh2, the catalytic subunit of the Polycomb Repressive Complex 2, is responsible for placing the epigenetic repressive mark histone H3 lysine 27 trimethylation (H3K27me3). I...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-09-09 | PXD010922 | Pride
Embryo 24hpf Zebrafish Ezh2 
GenomicsEGAS00001000462-sc-20141120 - samples
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAD00001001079 | EGA
TranscriptomicsThe tumor suppressor gene rap1GAP is silenced by mir-101-mediated EZH2 overexpression in invasive squamous cell carcinoma
Rap1GAP is a critical tumor suppressor gene that is down-regulated in multiple aggressive cancers such as head and neck squamous cell carcinoma, melanoma and pancreatic cancer. However, the mechanistic basis of rap1GAP down-regulation in cancers is poorly understood. By employing an integrative appr...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-28501 | biostudies-arrayexpress
GenomicsEGAS00001000462-sc-20170511 - samples
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAD00001003329 | EGA
UnknownmRNA Cap Methylation in Pluripotency and Differentiation.
Not available
S-EPMC4977272 | biostudies-literature
ProteomicsComprehensive analysis of vanillin toxicity in Escherichia coli identifies targets for engineering improved biovanillin production
One of the key issues affecting yields of biovanillin in cell factories such as Escherichia coli is product toxicity, the mechanisms of which are poorly understood. To identify targets for engineering improved strains, we have studied mechanisms of vanillin toxicity in E. coli using a two-pronged ap...
ORGANISM(S): Escherichia coli 
2019-05-29 | PXD009242 | Pride
Escherichia coli Stress response Aldehyde Citrate synthase Copper 
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
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