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ProteomicsA multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells
Okadaic acid (OA) is a marine biotoxin that can induce diarrheic shellfish poisoning upon consumption. It can accumulate in filter-feeding shellfish, thereby reaching the human food chain. In addition to inducing severe gastrointestinal symptoms, OA can pass the intestinal barrier into the bloodstre...
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD048968 | Pride
Liver proteome Heparg cells Muli-omics Okadaic acid Phosphoproteome 
GenomicsT-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism.
β-catenin signaling can be both a physiological and an oncogenic pathway in the liver. It controls compartmentalized gene expression, allowing the liver to ensure its essential metabolic function. It is activated by mutations in 20 to 40% of hepatocellular carcinomas with specific metabolic features...
ORGANISM(S): Mus musculus 
2014-01-18 | E-GEOD-35213 | biostudies-arrayexpress
TranscriptomicsPhenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors (mRNA)
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcino- genesis. Here, we have used a humanized CAR/PXR mo...
ORGANISM(S): Mus musculus 
2014-08-24 | E-GEOD-60684 | biostudies-arrayexpress
TranscriptomicsPhenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors (miRNA)
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcino- genesis. Here, we have used a humanized CAR/PXR mo...
ORGANISM(S): Mus musculus 
2014-08-24 | E-GEOD-60688 | biostudies-arrayexpress
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