Brain metastasis

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Metabolite Name

Carbamoyl Aspartate (2)
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Immuno-oncology (1)

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Transcription profiling by array (81)
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Lab affiliation

The Second Hospital of Dalian Medical University (4)
Department of Oncology-Pathology, Karolinska Institute and Scilifelab, Solna, Sweden (2)
Spanish National Cancer Research Center (CNIO) (2)
1) Vascular Biology Program, Boston Children's Hospital, Boston, MA, United States 2) Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States (1)
1Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada 2 Snyder Institute for Chronic Diseases, Hotchkiss Brain Institute and McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada (1)
Assistant Professor, Departments of Oncology & Pathology, McGill University Principal Investigator, Cancer Research Program, MUHC-RI 1001 Decarie Blvd, EM2.2218 514.934.1934 ext 76307 Montréal, Canada (1)
Barts Cancer Institute, Queen Mary University of London (1)
Biotech Research & Innovation Centre, University of Copenhagen, Denmark (1)
Centre for Proteomics and Metabolomics Leiden University Medical Centre (1)
Cutaneous Oncology/Tumor Biology Moffitt Cancer Center Tampa, FL, USA (1)
Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (1)
Department of Chemistry and Biochemistry, Texas Tech University (1)
Department of Clinical Sciences, Division of Clinical Protein Science and Imaging, Lund University, Sweden (1)
Department of Neurology and Neurooncology Program of the National Center for Tumor Diseases, Heidelberg University Hospital, Germany (1)
Department of Neurology, Laboratory of Neuro‑Oncology, Clinical and Cancer Proteomics, Erasmus University Medical Center (1)
Department of Oncology Pathology, Karolinska Institute, Solna, Sweden. (1)
Department of Pathology, Erasmus MC (1)
Department of Surgery Cedars-Sinai Medical Center (1)
Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (1)
Department of chemistry and biochemistry, Texas Tech University, Lubbock, Texas, USA, 79413. (1)
Fernando Garcia Martinez Ph.D. Proteomics & MS Specialist Proteomics Unit, Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro 3. E28029 MADRID, SPAIN. Phone +34 912246900 ext 3112 (1)
Lan head / Functional Proteomics Laboratory / Federal University of Sao Paulo / Sao Jose dos Campos, Sao Paulo, Brazil (1)
MD Anderson Cancer Center, Houston, TX (1)
Max Planck Institute for Biophysics Max Planck Institute of Brain Research (1)
Moffitt Cancer Center Tampa, FL, USA 33612 (1)
Molecular and Cellular Biology Department, University of Guelph, 50 Stone Rd. E. Guelph, Ontario, Canada, N1G 2W1 (1)
Pediatric Hematology-Oncology Research Laboratory, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Switzerland. (1)
Principal Investigator Universidade de Coimbra • Faculdade de Medicina | University of Coimbra • Faculty of Medicine Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR) | Coimbra Institute for Clinical and Biomedical Research (iCBR) (1)
Professor, Department of Molecular Genetics, University of Toronto, Canada Scientific Director, SPARC BioCentre, Hospital for Sick Children (Sickkids), Toronto, Canada (1)
Proteomics Unit Spanish National Cancer Research Centre (CNIO) ProteoRed-ISCIII Melchor Férnandez Almagro, 3 28029 Madrid. SPAIN (1)

Location

United States (5)
China (1)
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France (1)

Keyword

Brain metastasis (2)
GBM (2)
TMZ (2)
Bevacizumab (2)
First-In-Class Investigational Agent (1)
Peri-Nucleolar Compartment (PNC) (1)
Effective therapies against metastasis (1)
Oral Administration (1)
Maximum Recommended Starting Dose (1)
IDH-mutant (1)
IDH-wildtype (1)
Brain Metastases (1)
CNS Tumor (1)
NeOnc (1)
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NEO212 (1)
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Ferumoxytol (1)
Gastro-Esophageal Junction Adenocarcinoma (1)
Magnetic resonance imaging (1)
MM-398 (1)
Carboplatin (1)
TNBC (1)
Phase 1 (1)
Dose escalation (1)
Brain tumor (1)

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Targeted metabolomics of pancancer brain metastasis

The molecular heterogeneity of brain metastases hampers therapeutic development for cures. To address this unmet and urgent need, we constructed a comprehensive multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer brain metastases, identifying four robust molecular subtypes ...

2025-12-22 | MTBLS13554 | MetaboLights

Breast Brain Metastasis, Non-Neoplastic Brain, and Non-Neoplastic Breast Gene Expression

The central nervous system (CNS) is a common site of metastatic disease in patients with breast cancer and has few therapeutic options with dismal outcomes. The purpose of our study was to identify common and rare events that underlie breast cancer CNS metastasis. We performed deep genomic profiling...

ORGANISM(S): Homo sapiens

2014-03-13 | E-GEOD-52604 | biostudies-arrayexpress

MicroRNA profiling of brain metastasis competent cell-derived exosomes

Objective of this work was to characterize the miRNA profile of exosomes isolated from brain-homing cell lines (MDA-MB-231BR, CTC1BMSM, and 70W) with their respective parental non-brain metastatic cell lines (MDA-MB-231P, CTC1P and MeWo). Exosomes derived from the six cell lines were isolated. Brain...

ORGANISM(S): Homo sapiens

2013-07-16 | E-GEOD-48934 | biostudies-arrayexpress

Metabolic differences between primary and brain metastatic breast tumors revealed by in vivo [U-¹³C]-glucose infusion in mice

Metastatic breast tumors must adapt to the metabolic constraints of their target tissues. To understand how tumor metabolism varies across sites, we compared glucose utilization in primary mammary fat pad (MFP) tumors and brain metastases derived from the breast cancer cell line MDA-MB-231. Tumor...

2025-12-30 | MTBLS13152 | MetaboLights

Analyses of Human Brain Metastases of Breast Cancer Reveal the Association between HK2 Up-Regulation and Poor Prognosis

Analyses of Resected Human Brain Metastases of Breast Cancer Reveal the Association between Up-Regulation of Hexokinase 2 and Poor Prognosis. Brain metastases of breast cancer seem to be increasing in incidence as systemic therapy improves. Metastatic disease in the brain is associated with high mor...

ORGANISM(S): Homo sapiens

2010-01-21 | E-GEOD-20016 | biostudies-arrayexpress

DNA methylation analysis of melanoma progression to brain metastasis

Melanoma is one of the most aggressive and treatment-resistant cancers. It represents the most life-threatening neoplasm of the skin, and its incidence has been increasing for the last three decades. Melanoma evolves from the local transformation of melanocytes to primary tumors, which can metastasi...

ORGANISM(S): Homo sapiens

2013-09-19 | E-GEOD-44661 | biostudies-arrayexpress

Melanoma experimental metastasis model

Application of a melanoma experimental metastasis model to elucidate molecular mediators of melanoma brain metastasis. Malignant melanoma frequently metastasizes to the brain. The molecular mediators of brain metastasis still remains largely unknnown. Two melanoma cell lines (opposing phenotypes in ...

ORGANISM(S): Homo sapiens

2014-02-26 | E-MTAB-2065 | biostudies-arrayexpress

Affymetrix expression array data for melanoma progression to the brain

ORGANISM(S): Homo sapiens

2013-09-19 | E-GEOD-44660 | biostudies-arrayexpress

Transcription profiling of human primary breast tumors

Brain metastasis is one of the most feared complications of cancer and the most common intracranial malignancy in adults. Its underlying mechanisms remain unknown. From breast cancer patients with metastatic disease we isolated cell populations that aggressively colonize the brain. Transcriptomic an...

ORGANISM(S): Homo sapiens

2009-06-23 | E-GEOD-12276 | biostudies-arrayexpress

Brain metastasis from lung adenocarcinoma patients

Microarray analysis of 28 brain metastasis samples from lung adenocarcinoma patients. 28 brain metastasis samples: 19 from Marc Ladanyi 9 from William L. Gerald

ORGANISM(S): Homo sapiens

2010-06-17 | E-GEOD-14108 | biostudies-arrayexpress

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