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TranscriptomicsTranscription profiling of rat eye eQTL experiment
We used expression quantitative trait locus mapping in the laboratory rat (Rattus norvegicus) to gain a broad perspective of gene regulation in the mammalian eye and to identify genetic variation relevant to human eye disease. Of >31,000 gene probes represented on an Affymetrix expression microarray...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5680 | biostudies-arrayexpress
TranscriptomicsA Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, Toxoplasma actively remodels the transcriptome of its hosting cells with profound and coupled impact on the host immune response. ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-38782 | biostudies-arrayexpress
TranscriptomicsToxoplasma TgIST co-opts Host Chromatin Repressors dampening STAT1-dependent gene regulation and IFN-γ-mediated host defenses
An early hallmark of Toxoplasma infection is the rapid control of the parasite population by a potent multifaceted innate immune response that engages resident and homing immune cells along with pro- and counter-inflammatory cytokines. In this context, IFN-γ activates a variety of Toxoplasma-target...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-81613 | biostudies-arrayexpress
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