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ProteomicsThe impact of codon usage from bicistronic mRNA on their transcriptomic, post-transcriptomic and proteomic regulation in human cells
A large amount of virus infecting humans expresses polycistronic mRNAs on which viral ORF display codon usages (CU) dissimilar to the average human ORF CU. Among those viruses, oncogenic Human Papillomavirus (HPV) are responsible for 5% of all cancer cases. It is known that CU is a major step of bot...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047576 | Pride
Codon usage U-2 os Splicing Transcript Polycistronic mrna Bicistronic mrna Translation 
ProteomicsTranscriptomic, proteomic and functional consequences of codon usage bias in human cells
Differences in codon frequency between genomes, genes, or positions along a gene, modulate transcription and translation efficiency, leading to phenotypic and functional differences. Integrative studies quantifying the phenotypic consequences of codon usage bias at different molecular and cellular l...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD038324 | Pride
Culture Mass spectrometry Hek-293 
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