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GenomicsCombined deficiency of Tet1 and Tet2 is compatible with development but leads to epigenetic instability
Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 and Tet2 mediate 5hmC generation in mouse embryonic stem cells (ESCs) and various embryonic and adult tissues. To investigate the effects of combined deficiency of Tet1 and Tet2 on pluripotency and developm...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-42396 | biostudies-arrayexpress
TranscriptomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Infinium HumanMethylation450 Beadchip)
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we used the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modif...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-32362 | biostudies-arrayexpress
GenomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
This SuperSeries is composed of the following subset Series: GSE32362: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Illumina HumanMethylation450 BeadChip) GSE33129: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mamm...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-33130 | biostudies-arrayexpress
GenomicsLoss of Tet enzymes compromises proper differentiation of embryonic stem cells
Tet enzymes (Tet1/2/3) catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and are dynamically expressed in various embryonic and adult cell types. While loss of individual Tet enzymes or combined deficiency of Tet1/2 allows for embryogenesis, the effect of complete ...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-55049 | biostudies-arrayexpress
GenomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (MeDIP-Seq)
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we used the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modif...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-33129 | biostudies-arrayexpress
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