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TranscriptomicsTranscriptomic profiling of Arabidopsis exposed to E-2-hexenal
Plants are known to be responsive to volatiles, but knowledge about the molecular players involved in transducing their perception remain scarce. Here the response of Arabidopsis thaliana to E-2-hexenal, one of the green leaf volatiles that are produced upon wounding, herbivory or infection with pat...
ORGANISM(S): Arabidopsis thaliana 
2015-09-08 | E-GEOD-53957 | biostudies-arrayexpress
TranscriptomicsDissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.
Under REACH, the European Community Regulation on chemicals, the testing strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Given that non-genotoxic carcinogens are negative for genotoxicity, this class of carcinogens will not be detected. Therefore, alterna...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-35058 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type, p53 Ser389 phosphorylation site point mutant and p53 knock-out mouse embryonic fibroblasts after exposure to UV radiation for different lengths of time
Comparison of responses of mouse wild-type, p53 Ser389 phosphorylation site point mutant and full knock-out mutant MEF cells to UV-C-radiation in time
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1397 | biostudies-arrayexpress
TranscriptomicsAging Experiment
Lifelong murine gene expression profiles in relation to chronological and biological aging in multiple organs Five tissues: Kidney, Liver, Lung, Spleen, Brain. Six timepoints: 13wks, 26 wks, 52wks, 78wks, 104wks, 130wks. One Genotype: C57Bl/6, 3 replicates
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-34378 | biostudies-arrayexpress
TranscriptomicsEvaluation of ribonucleic acid amplification protocols for human oocyte transcriptome analysis
Objective: To develop a reliable, reproducible, and sensitive method for investigating gene-expression profiles from individual human oocytes. Setting: University medical center and university microarray laboratory. Patient(s): Couples undergoing intracytoplasmic sperm injection treatment were aske...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-48141 | biostudies-arrayexpress
TranscriptomicsConfounding factors in the analysis of the transcriptome response to UV exposure in skin of wild-type and human p53-variant mice
An in-vivo experiment with UV-B exposure of the skin of nude, male mice, with and without human-derived p53 variants in their genome to investigate the cellular responses upon UV-induced DNA damage. Essentially, 4 replicate mice were used for each level of UV-exposure. For each mouse a biopsy of the...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-63044 | biostudies-arrayexpress
TranscriptomicsCombining Next-Generation Sequencing and Microarray Technology into a Transcriptomics Approach for the Non-Model Organism Chironomus riparius
Whole-transcriptome gene-expression analyses are commonly performed in species that have a sequenced genome and for which microarrays are commercially available. To do such analyses in species with no or limited genome data, i.e. non-model organisms, necessary transcriptomics resources, i.e. an anno...
ORGANISM(S): Anopheles gambiae 
2014-05-19 | E-GEOD-53449 | biostudies-arrayexpress
TranscriptomicsUV-C dose and time range finding study on Mouse Embryonic Fibroblasts (MEFs)
In molecular biology, the design of mechanistic experiments has to be optimized by considering statistical and biological principles. In contrast to statistical principles, biological principles of experimental design are not universally formulated. In an attempt to pinpoint generally acceptable rul...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-50930 | biostudies-arrayexpress
TranscriptomicsUV-B dose and time range finding study on mouse biopsy skin samples
In molecular biology, the design of mechanistic experiments has to be optimized by considering statistical and biological principles. In contrast to statistical principles, biological principles of experimental design are not universally formulated. In an attempt to pinpoint generally acceptable rul...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-51348 | biostudies-arrayexpress
TranscriptomicsEffect of multiple longitudinal biopsy sampling in individual mice
Small scale study to asses the effects of taking multiple skinbiopts from individual mice in time. Results showed no influence on expression levels in time from older samplings on newer samplings. skin biopts from 4 individual mice in taken at 6 points in time
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-51347 | biostudies-arrayexpress
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