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UnknownAre large clinical trials in orthopaedic trauma justified?
BACKGROUND:The objective of this analysis is to evaluate the necessity of large clinical trials using FLOW trial data. METHODS:The FLOW pilot study and definitive trial were factorial trials evaluating the effect of different irrigation solutions and pressures on re-operation. To explore treatment e...
S-EPMC5909275 | biostudies-literature
UnknownWound irrigation does not affect health-related quality of life after open fractures: results of a randomized controlled trial.

Aims

The Fluid Lavage in Open Fracture Wounds (FLOW) trial was a multicentre, blinded, randomized controlled trial that used a 2 × 3 factorial design to evaluate the effect of irrigation solution (soap versus normal saline) and irrigation pressure (very low versus low versus...
S-EPMC6413805 | biostudies-literature
UnknownFactors Associated With Revision Surgery After Internal Fixation of Hip Fractures.
BACKGROUND:Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck...
S-EPMC5986292 | biostudies-literature
UnknownFracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial.

Background

Reoperation rates are high after surgery for hip fractures. We investigated the effect of a sliding hip screw versus cancellous screws on the risk of reoperation and other key outcomes.

Methods

For this international, multicentre, allocation concealed randomised controlled ...
S-EPMC5597430 | biostudies-literature
UnknownFixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures.

Background

Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controvers...
S-EPMC4230242 | biostudies-literature
UnknownFunctional outcome after successful internal fixation versus salvage arthroplasty of patients with a femoral neck fracture.

Objectives

To determine patient independency, health-related and disease-specific quality of life (QOL), gait pattern, and muscle strength in patients after salvage arthroplasty for failed internal fixation of a femoral neck fracture.

Design

Secondary cohort study to a randomized cont...
S-EPMC4233012 | biostudies-literature
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