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ProteomicsComposition of Rosenthal fibers in Alexander disease patients and mouse models
Alexander disease (AxD) is a fatal neurodegenerative disorder characterized by the presence in astrocytes of protein aggregates called Rosenthal fibers (RFs). In this work, we used a new biochemical fractionation method to enrich for RFs followed by analysis of this fraction using quantitative iTRA...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-05-23 | PXD002448 | Pride
Alexander disease Rosenthal fibers Itraq 8-plex 
TranscriptomicsAnalysis of temporal mRNA expression changes in cultured keratinocytes from Casp-8F/M-bM-^@M-^SK5-Cre and Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17345 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis Col-0 wild-type and 35S:ARR1-SRDX transgenic seedlings either induced with 6-Benzyladenine or mock-treated
6 days old Arabidopsis thaliana of Col-0 wild-type and 35S:ARR1-SRDX transgenic seedlings grown in liquid culture (1/2 MS, 1 g/L sucrose, 0.5 g/L MES, pH 5.7) were induced with either 5 µM 6-Benzyladenine (a cytokinin analog) for 15 or 120 min, or mock-treated 120 min as a control. These samples wer...
ORGANISM(S): Arabidopsis thaliana 
2008-07-03 | E-ATMX-11 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of 1-methylnicotinamide (MNA) and nicotinic acid (NA)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan of different species. Contrasting recent observations, we here find that overexpression of sir-2.1, the orthologue of mammalian SirT1, does extend C. elegans lifespan. Sirtuins are known to convert NAD+ i...
ORGANISM(S): Caenorhabditis elegans 
2013-08-09 | E-GEOD-49662 | biostudies-arrayexpress
UnknownLincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.
Not available
S-EPMC5088508 | biostudies-literature
TranscriptomicsTranscription profiling of 5 to 7 days old Arabidopsis thaliana seedlings of wild type (Col-0) and the cytokinin deficient transgenic line 35S:CKX1
5 to 7 days old Arabidopsis thaliana seedlings of wildtype (Col-0) and the cytokinin deficient transgenic line 35S:CKX1 (Werner et al. Plant Cell 15, 2532) at growth stage 1.00 (Boyes scale) grown in liquid medium were induced witn 5 µM 6-Benzylaminopurine for different periods of time in order to f...
ORGANISM(S): Arabidopsis thaliana 
2005-07-31 | E-MEXP-344 | biostudies-arrayexpress
UnknownComplete Genome Sequence of Mannheimia haemolytica Strain 42548 from a Case of Bovine Respiratory Disease.
Not available
S-EPMC3668016 | biostudies-literature
TranscriptomicsmodENCODE Drosophila RNA Binding Protein RNAi RNA-Seq Studies
Deep Sequencing of mRNA from the Drosophila melanogaster S2-DRSC cells that have been RNAi depleted of mRNAs encoding RNA binding proteins. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFina...
ORGANISM(S): Drosophila melanogaster 
2009-10-09 | E-GEOD-18508 | biostudies-arrayexpress
TranscriptomicsAnalysis of spatial mRNA expression differences in the skin of Casp-8F/–K5-Cre or Casp-8F/+K5-Cre mice
Expression of enzymatically inactive caspase-8, or deletion of caspase-8 from basal epidermal keratinocytes, triggers chronic skin inflammation in mice. Unlike similar inflammation resulting from arrest of NF-kB activation in the epidermal cells, the effect induced by caspase-8 deficiency did not de...
ORGANISM(S): Mus musculus 
2009-07-29 | E-GEOD-17344 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of C. elegans mina-1 mutants
Comparative transcriptomics study between C. elegans wild-type N2 and mina-1 mutants.
ORGANISM(S): Caenorhabditis elegans 
2019-02-13 | E-MTAB-7389 | biostudies-arrayexpress
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