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TranscriptomicsRecombination initiation maps of individual human genomes
DNA double-strand breaks (DSBs) are introduced in meiosis to initiate recombination and to generate crossovers, the reciprocal exchanges of genetic material between parental chromosomes. Here we present the first high-resolution map of meiotic DSBs in individual human genomes. Comparing DSB maps bet...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-59836 | biostudies-arrayexpress
GenomicsSupression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic spo11 allele
Homologous recombination is the key process that generates genetic diversity and drives evolution. SPO11 protein triggers recombination by introducing DNA double stranded breaks at discreet areas of the genome called recombination hotspots. The hotspot locations are largely determined by the DNA bin...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-48493 | biostudies-arrayexpress
GenomicsGenome-wide assay of Vezf1 and RNA Polymerase II binding
The protein Vezf1 plays multiple roles important for embryonic development. In Vezf1-/- mouse embryonic stem (MES) cells our earlier data showed widespread changes in gene expression profiles, including decreased expression of the full length active isoform of Dnmt3b methyltransferase and concomitan...
ORGANISM(S): Mus musculus 
2012-03-09 | E-GEOD-34785 | biostudies-arrayexpress
GenomicsMediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA
CCCTC-binding factor (CTCF) is a DNA-binding protein that plays important roles in chromatin organization, though the mechanism by which CTCF carries out these functions is not fully understood. Recent studies show that CTCF recruits the cohesin complex to insulator sites and that cohesin is require...
ORGANISM(S): Homo sapiens 
2010-11-16 | E-GEOD-24126 | biostudies-arrayexpress
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