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TranscriptomicsCircadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo
Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock.  We have determined the underlying mechanisms by measuring nascent RNA transcription around the clock in mouse liver. Unbiased ex...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-59460 | biostudies-arrayexpress
ProteomicsRab5a-VPS34 unnatural amino acid mediated crosslinking
The small GTPase Rab5 has an essential role in sorting vesicles arriving to and leaving the early endosome. One key function of Rab5 in this process is the activation of the primordial phosphatidylinositol 3-kinase VPS34, a lipid kinase that phosphorylates phosphatidylinositol (PI) to generate PI3P....
ORGANISM(S): Homo Sapiens (human) 
2021-12-21 | PXD023533 | JPOST Repository
TranscriptomicsIntegration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology
Down syndrome (DS) is the most frequent cause of human congenital mental retardation. Cognitive deficits in DS result from perturbations of normal cellular processes both during development and in adult tissues, but the mechanisms underlying DS etiology remain poorly understood. To assess the abilit...
ORGANISM(S): Homo sapiens 
2012-12-17 | E-GEOD-42956 | biostudies-arrayexpress
UnknownSynthetic Phosphorylation Networks with Fluorescence and Luminescence Expansion.
Not available
S-EPMC12186673 | biostudies-literature
UnknownAre there differences in symptoms experienced by midlife climacteric women with and without metabolic syndrome? A scoping review.
Not available
S-EPMC8918770 | biostudies-literature
TranscriptomicsTranscription profiling of 100 Arabidopsis Col/Ler recombinant inbred lines to generate a high-density genetic linkage map
The aim of this study was to generate a high-density genetic linkage map of Arabidopsis. A custom-designed exon-specific whole-genome array was used to identify ~16,000 significant SFP markers between the parental accessions Col and Ler. Subsequently 100 Col/Ler recombinant inbred lines (RILs) were ...
ORGANISM(S): Arabidopsis thaliana 
2006-09-01 | E-TABM-135 | biostudies-arrayexpress
UnknownNeuroscience Cloud Analysis As a Service: An open-source platform for scalable, reproducible data analysis.
Not available
S-EPMC9464703 | biostudies-literature
TranscriptomicsTrichuris muris infection drives cell-intrinsic IL4R alpha independent large intestinal RELMα+ macrophages.
The RELMα+ macrophage phenotype associates with the presence of anti-inflammatory macrophages and work in other model systems has demonstrated that the balance of pro-inflammatory and anti-inflammatory macrophages is critically important in enabling the resolution of inflammation. Moreover, in the c...
ORGANISM(S): Mus musculus 
2021-11-15 | E-MTAB-10501 | biostudies-arrayexpress
TranscriptomicsIdentification of circadian transcripts that are co-regulated with [Ca2+]cyt
Our aim is to identify circadian transcripts that are co-regulated with [Ca2+]cyt, with the eventual goal of identifying genetic regulators and targets for circadian oscillations of [Ca2+]cyt. We have identified two conditions in which [Ca2+]cyt behaves differently to other circadian outputs. 1. ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-09 | E-GEOD-19271 | biostudies-arrayexpress
TranscriptomicsTranscriptome of Arabidopsis thaliana ceh1 mutant
Here we present the transcriptomic profile of mutant plants designated as ceh1 (constitutively expressing HPL). CEH1 encodes 1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase (HDS), the enzyme controlling the bottleneck step of the biosynthesis of isopentenyl diphosphate via the 2-C-methyl-d-eryth...
ORGANISM(S): Arabidopsis thaliana 
2014-09-24 | E-GEOD-61675 | biostudies-arrayexpress
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