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ProteomicsSelective Macrocyclic Peptide Modulators of Lys63-linked Ubiquitin Chains Disrupt DNA Damage Repair
Developing an effective binder for a specific ubiquitin (Ub) chain is a promising approach for modulating various biological processes with potential applications in drug discovery. In this study, we combined the Random Non-standard Peptides Integrated Discovery (RaPID) method and chemical protein s...
ORGANISM(S): Homo sapiens (Human) 
2022-09-19 | PXD035924 | Pride
Ubiquitin Dna damage repair 
TranscriptomicsRNF20 and USP44 regulate embryonic stem cell differentiation by modulating H2B monoubiquitylation
Embryonic stem cells (ESCs) maintain high genomic plasticity, essential for their capacity to enter diverse differentiation pathways. Post-transcriptional modifications of chromatin histones play a pivotal role in maintaining this plasticity. We now report that one such modification, monoubiquitylat...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-33214 | biostudies-arrayexpress
TranscriptomicsNucleosome positioning in H3S57 mutants in yeast
In order to test the effect of H3S57 phosphorylation on nucleosome positioning in yeast, nucleosome were mapped in a WT strain, a strain with H3S57A mutation (phospho absent) and a strain H3S57E mutation (phospho mimicking).
ORGANISM(S): Saccharomyces cerevisiae 
2020-12-20 | E-MTAB-6901 | biostudies-arrayexpress
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