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TranscriptomicsGene expression array assay of Lsh WT and Knockout MEF cells
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and contribute to genome-wide methylation patterns remain elusive. Here, we report a hi...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-29392 | biostudies-arrayexpress
GenomicsH3K4me3 modification analysis comparing Lsh WT and Lsh-/- MEFs
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and contribute to genome-wide methylation patterns remain elusive. Here, we report a hi...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-29393 | biostudies-arrayexpress
TranscriptomicsComprehensive genomic map of cytosine methylation for wild-type (WT) and Lsh-/- mouse embryonic fibroblasts
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and contribute to genome-wide methylation patterns remain elusive. Here, we report a hi...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-29394 | biostudies-arrayexpress
GenomicsWhole genome shotgun bisulfite sequencing of the Lsh-/- and Lsh+/+ murine embryonic fibroblasts and ES cells
Whole-genome single-base resolution methylcytosine map reveals profound changes that occur after Lsh deletion during embryonic development in primary WT and Lsh-/- MEFs. Lsh deletion leads to widespread decreases of CG methylation level at uniquely mapped genomic regions compared to wild type, inclu...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-57486 | biostudies-arrayexpress
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