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TranscriptomicsTranscription profiling of human estrogen-dependent model of breast cancer created by transformation of normal mammary epithelial cells
This study was performed to check that ESR1 and BMI1 are biologically active after lentiviral transduction of primary human mammary epithelial cells (HMECs) with lentiviral vectors expressing ESR1 and BMI1 from the human PGK promoter. ESR1 targets like PGR, PRLR and GREB1, but not TFF1 and XBP1, wer...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6548 | biostudies-arrayexpress
TranscriptomicsmiR-148b modulates the expression of multiple genes
To identify which miR-148b targets were involved in tumorigenesis, a microarray analysis was performed for miR-148b over-expressing cells versus controls and 129 (49 up and 80 down) modulated genes were revealed. The effects of miR-148b on cancer progression depend on the direct and indirect regulat...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26662 | biostudies-arrayexpress
TranscriptomicsmicroRNA and cancer progression in breast tumors
miRNAs are small non-coding RNAs frequently altered in human malignancies. They regulate protein-coding gene expression by mediating mRNA degradation and/or repressing translation via the association with the 3M-bM-^@M-^Y untranslated region (3M-bM-^@M-^Y UTR) of the mRNAs. Aberrant miRNA expression...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26659 | biostudies-arrayexpress
TranscriptomicsmiR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS and CSF1
Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we analyzed miR expression in 77 primary breast carcinomas and identified 16 relapse-associated miRs that correlate with survival and/or distinguish tumor subtypes in differen...
ORGANISM(S): Homo sapiens 
2012-12-16 | E-GEOD-26666 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human inflammatory breast carcinoma tumors (luminal, basal and apocrine)
EORTC 10994 is a phase III clinical trial comparing FEC with ET in patients with large operable, locally advanced or inflammatory breast cancer (www.eortc.be). Frozen biopsies were taken at randomisation. RNA was extracted from 100um thickness of 14G core needle biopsies. Adjacent sections were test...
ORGANISM(S): Homo sapiens 
2007-08-14 | E-GEOD-1561 | biostudies-arrayexpress
TranscriptomicsPhysical and functional CSL-p53 interactions underlie control of cancer stromal cell evolution [RNA-seq]
Senescence of stromal fibroblasts has been linked to establishment of cancer associated fibroblasts (CAF) and aging-associated increase of tumors. However, in clinically occurring carcinomas, density and proliferation of CAFs are frequently increased rather than decreased. We previously showed that ...
ORGANISM(S): Homo sapiens 
2015-08-24 | E-GEOD-65473 | biostudies-arrayexpress
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