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MetabolomicsMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here w...

2020-06-29 | MTBLS1764 | MetaboLights
TranscriptomicsActivating transcription factor 3 regulates immune and metabolic homeostasis
Integration of metabolic, stress and immune responses plays a fundamental role during animal development to maintain energy homeostasis while ensuring growth and proper developmental timing. Perturbation of metabolic and immune signaling circuits has detrimental consequences to animal development in...
ORGANISM(S): Drosophila melanogaster 
2012-11-05 | E-GEOD-36377 | biostudies-arrayexpress
TranscriptomicsLiver adapts mitochondrial function to insulin-resistant and diabetic states in mice
Objective: To study if diabetic and insulin-resistant states lead to mitochondrial dysfunction in the liver, or alternatively, if there is adaption of mitochondrial function to these states in the long-term range. Results: High-fat diet (HFD) caused insulin resistance and severe hepatic lipid accum...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-39752 | biostudies-arrayexpress
MetabolomicsLipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy
As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss of function of the LPIN1 gene frequently lead to severe rhabdomyolysis bouts in children, though the metabolic alterations an...
2019-01-07 | MTBLS750 | MetaboLights
ProteomicsPhosphoproteomics of the developing heart identifies PERM1 - an outer mitochondrial membrane protein
Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-21 | MSV000085796 | MassIVE
MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
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