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TranscriptomicsRNA-seq of human monocyte-derived macrophages in response to Salmonella infection and Chlorpromazine treatment
RNA-seq was performed to determine the transcriptional response of human monocyte-derived macrophages to Salmonella infection and whether Chlorpromazine affected this response. These data were used to determine whether enhanced killing capacity of Chlorpromazine treated cells was due to transcriptio...
ORGANISM(S): Homo sapiens 
2023-01-01 | E-MTAB-7232 | biostudies-arrayexpress
TranscriptomicsTolerogenic dendritic cells protect against acute kidney injury
We use tolDCs from syngeneic (C57BL6) and allogeneic (BALB/c) mice to show potent renoprotective abilities in a ischemia reperfusion AKI model. Dendritic cells were derived from mice bone marrow and cultured for 7 days with GM-CSF and IL-4. Tolerogenic DCs were cultured in the same DC media but with...
ORGANISM(S): Mus musculus 
2024-11-25 | E-MTAB-14618 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of WT and the yqhC mutant of Salmonella using Illumina Genome Analyzer II
Total RNA was isolated from WT and the mutant and the ribosomal RNA was removed using Ambion Kit. Construction of cDNA library, addition of adapters and sequence read were performed. 2 samples were used, WT Salmonella and its yqhC mutant
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2011-09-29 | E-GEOD-24263 | biostudies-arrayexpress
GenomicsAbo1, a conserved bromodomain AAA-ATPase maintains global nucleosome occupancy and organization
Maintenance of the correct level and organization of nucleosomes is crucial for genome function. Here we uncover a role for a conserved bromodomain AAA-ATPase, Abo1, in maintenance of nucleosome architecture in fission yeast. Cells lacking abo1+ experience both a reduction and mis-positioning of nuc...
ORGANISM(S): Schizosaccharomyces pombe 
2015-10-30 | E-GEOD-67410 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of the 16-cell stage Ciona embryo
Ciona develops according to a stereotyped or invariant lineage. This allowed us to collect precisely defined replicates of all eight blastomeres of the right half of the embryo at the 16-cell stage of Ciona. We manually dissected each embryo, collecting and identifying each cell before library prepa...
ORGANISM(S): Ciona robusta 
2020-03-06 | E-MTAB-6117 | biostudies-arrayexpress
TranscriptomicsHuman nuclear Dicer restricts the deleterious accumulation of endogenous double strand RNA
Dicer is a central enzymatic player in RNA interference (RNAi) pathways that acts to regulate gene expression in nearly all eukaryotes. Although the cytoplasmic function of Dicer is well documented in mammals, there is little known about any possible nuclear function. Here we show that Dicer is pre...
ORGANISM(S): Homo sapiens 
2014-04-10 | E-GEOD-56648 | biostudies-arrayexpress
UnknownEffects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage: Extended Follow-up of the RESTART Randomized Clinical Trial.
Not available
S-EPMC8417806 | biostudies-literature
UnknownThe REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.
Not available
S-EPMC5838871 | biostudies-literature
UnknownEffects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial.
Not available
S-EPMC6617509 | biostudies-literature
UnknownEffects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial.
Not available
S-EPMC7645733 | biostudies-literature
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