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UnknownSingle-cell transcriptomics identifies an effectorness gradient shaping the response of CD4<sup>+</sup> T cells to cytokines.
Not available
S-EPMC7156481 | biostudies-literature
UnknownThe JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.
Not available
S-EPMC4431345 | biostudies-literature
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer: cell line data
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumor-suppressor pathways. The quest to personalize cancer medicine based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumor suppresso...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23873 | biostudies-arrayexpress
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer: tumor data
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumor-suppressor pathways. The quest to personalize cancer medicine based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumor suppresso...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23874 | biostudies-arrayexpress
UnknownAn Escherichia coli O157-specific engineered pyocin prevents and ameliorates infection by E. coli O157:H7 in an animal model of diarrheal disease.
Not available
S-EPMC3232761 | biostudies-literature
UnknownImmune disease risk variants regulate gene expression dynamics during CD4+ T cell activation.
Not available
S-EPMC9197762 | biostudies-literature
MetabolomicsThe pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication

BACKGROUND: In all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate genome duplication prior to cell division. Failures in this regulation cause DNA damage with potentially disastrous consequences ...

2022-04-19 | MTBLS4415 | MetaboLights
UnknownTherapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma.
Not available
S-EPMC6541653 | biostudies-literature
UnknownCD117-Targeted Intraoperative Imaging of Gastrointestinal Stromal Tumor Using a Stem-Cell-Factor-Labeled Fluorophore.
Not available
S-EPMC12499596 | biostudies-literature
UnknownUsing combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors.
Not available
S-EPMC4054699 | biostudies-literature
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