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TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer: cell line data
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumor-suppressor pathways. The quest to personalize cancer medicine based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumor suppresso...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23873 | biostudies-arrayexpress
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer: tumor data
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumor-suppressor pathways. The quest to personalize cancer medicine based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumor suppresso...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23874 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary tumors from K14-cre; ApcCKO/+ vs control mammary glands
Many components of Wnt/β-catenin signaling pathway also play critical roles in mammary tumor development. To study the role of Apc in mammary tumorigensis, we introduced conditional Apc mutations specifically into two different mammary epithelial populations using K14-Cre (progenitor) and WAP-cre ...
ORGANISM(S): Mus musculus 
2009-02-21 | E-GEOD-14753 | biostudies-arrayexpress
TranscriptomicsNuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed only after it has metastasized to distant sites (Meuwissen and Berns 2005; Cooper and Spiro 2006). Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels (Forgacs ...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29533 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of naked mole rat, Heterocephalus glaber
Deep sequencing of mRNA from naked mole rat Analysis of ploy(A)+ RNA of different specimens: brain, kidney, liver from new born , 4 years old , 20 years old and 4 years old hypoxia-exposed naked mole rat
ORGANISM(S): Heterocephalus glaber 
2011-10-12 | E-GEOD-30337 | biostudies-arrayexpress
TranscriptomicsGermline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase, and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. To interrogate the functional requirement for PKM2 during development and tissue homeostasis, we generated ge...
ORGANISM(S): Mus musculus 
2016-03-25 | E-GEOD-79535 | biostudies-arrayexpress
TranscriptomicsLKB1 modulates lung cancer differentiation and metastasis
Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6135 | biostudies-arrayexpress
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