Investigates the effect of shRNA knock-down of JNK1, JNK2, JNK3 in INS-1 insulin producing cells compared to untransfected INS-1 cells before and after treatment with IL-1beta for 45 min and 6 h.
B6.Cg-Lep ob/ob mice females were surgically implanted in an age of 10-12 weeks with Alzet osmotic mini pumps (model 1002, 0,25l/h, Cupertino, CA, USA) in two groups of ten mice each to perform continuous subcutaneous infusions of Dulbecco's phosphate buffered saline (vehicle; n = 8) or GLP-1 (GLP-1...
