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TranscriptomicsIdentification of molecular key determinants of the Mycobacterium abscessus smooth and rough morphotypes through transcriptome analyses
In this study, we were interested to get deeper insights into the molecular mechanisms that govern the formation and selection of the different colony morphologies in Mycobacterium abscessus strains, including the potential reversibility of the rough (R) phenotype into a smooth (S) phenotype. We use...
ORGANISM(S): Mycobacterium abscessus 
2013-05-15 | E-GEOD-37984 | biostudies-arrayexpress
TranscriptomicsDissecting the immunogenicity of RD1-recombinant live tuberculosis vaccine candidates studying host-pathogen interaction in human primary dendritic cells
New tuberculosis vaccines are highly desirable and urgently needed since the attenuated Mycobacterium bovis Bacillus Calmette-Guerin (BCG) provides only variable efficacy against the pulmonary form of the disease. The region of difference 1 (RD1), which is deleted in BCG and strongly impacts on Myco...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-62423 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium bovis with pYUB412 and pRD1-2F9 genes knocked-in to investigate the ESX-1 secretion system
The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10 kDa culture filtrate protein CFP-10, and is missing from the vaccine strains M.bovis BCG and M.microti. Here, we systematically ...
ORGANISM(S): Mycobacterium bovis 
2007-01-30 | E-BUGS-31 | biostudies-arrayexpress
TranscriptomicsEvolutionary conserved mutations in PhoPR attenuate the virulence of animal-adapted tuberculosis strains for humans
By genome comparison of 30 MTBC strains, we identified three SNPs affecting the phoPR genes of members of the animal and M. africanum lineages that were not seen in the M. tuberculosis sensu-stricto genomes. The genes phoPR encode a two component regulatory system that is known for its strong impact...
ORGANISM(S): Mycobacterium tuberculosis 
2014-07-07 | E-GEOD-54421 | biostudies-arrayexpress
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