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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart response to hypoxia treatment of parental Fawn Hooded Hypertensive (FHH) and consomic Brown Norway (FHH1BN) rat
Examination of gene expression associated with hypoxia treatment of parental Fawn Hooded Hypertensive (FHH) and consomic Brown Norway (FHH1BN) rat strain. FHH1BN rats are derived from introgression of chromosome 1 from BN rats into the FHH genetic background.
ORGANISM(S): Rattus rattus 
2006-01-15 | E-TIGR-24 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat lung response to hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SSYBN) rat strain
Examination of gene expression associated with hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SSYBN) rat strain. SSYBN rats are derived from introgression of chromosome Y from BN rats into the SS genetic background.
ORGANISM(S): Rattus rattus 
2005-01-01 | E-TIGR-80 | biostudies-arrayexpress
MetabolomicsGrowth control of the eukaryote cell: a systems biology study in yeast
Metabolic control analysis is being exploited in a systems biology study of the eukaryotic cell. Using chemostat culture, we have measured the impact of changes in flux (growth rate) on the transcriptome, proteome, endometabolome and exometabolome of the yeast Saccharomyces cerevisiae. Each function...
2012-04-19 | MTBLS8 | MetaboLights
TranscriptomicsHuman brown and white preadipocyes clonal dynamics predict themorgenic potential and function
Brown adipose tissue (BAT) holds therapeutic potential for obesity and metabolic syndrome via increasing energy expenditure. Both inter- and intra-individual differences contribute to heterogeneity in human BAT and potentially to differential thermogenic capacity in human populations. Here, we demon...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-GEOD-68544 | biostudies-arrayexpress
TranscriptomicsCold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver
Cold exposure imposes a metabolic challenge to mammals that must be met by a coordinated repsonse in different tissues to prevent hypothermia. This study reports analysis of transcriptome profiles in brown adipose tissue, liver, white adipose of mice in repsonse to 24 hour cold exposure Total RNA wa...
ORGANISM(S): Mus musculus 
2013-07-08 | E-GEOD-44138 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart during hypoxia of the Fawn Hooded Hypertensive (FHH) rat and FHH12BN consomic rat
Examination of gene expression changes during hypoxia of the Fawn Hooded Hypertensive (FHH) rat and FHH12BN consomic rat. FHH12BN rats are derived from introgression of chromosome 12 and from the Brown Norway (BN) rat into the FHH genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-111 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from Dahl salt sensitive (SS) rats and SS4BN consomic rats during hypoxia treatment
Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS4BN consomic rat. SS4BN rats are derived from introgression of chromosome 4 from Brown Norway (BN) rat into the genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-118 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from Dahl salt sensitive (SS) rats and SS11BN consomic rats during hypoxia treatment
Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS11BN consomic rat. SS11BN rats are derived from introgression of chromosome 11 from Brown Norway (BN) rat into the SS genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-116 | biostudies-arrayexpress
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