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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
ProteomicsBioactive Molecular Networking for Mapping the Antimicrobial Constituents of the Baltic Brown Alga Fucus vesiculosus
mgf files, quantification tables and metadata files used in the publication Buedenbender et al., "Bioactive Molecular Networking for Mapping the Antimicrobial Constituents of the Baltic Brown Alga Fucus vesiculosus", Marine Drugs, 2020
ORGANISM(S): Fucus Vesiculosus (ncbitaxon:49266) 
2020-06-02 | MSV000085539 | MassIVE
TranscriptomicsSingle nucleus RNA sequencing of human deep neck BAT
single-nucleus RNA sequencing is applied on human brown adipose tissue at deep neck.
ORGANISM(S): Homo sapiens 
2020-07-13 | E-MTAB-8564 | biostudies-arrayexpress
TranscriptomicsDifferential Effects Of The Anti-Obesity Drug Tirzepatide On Adipose Tissues: Brown Fat As A Key Target
Tirzepatide is an anti-obesity drug based on dual agonism of the incretin receptors GLP-1R and GIPR. Its anti-obesity effect is largely based on its action of reducing food intake. However, there are suggestive indications that tirzeparide may exert effects on adipose tissues beyond those resulting ...
ORGANISM(S): Mus musculus 
2026-02-16 | E-MTAB-15994 | biostudies-arrayexpress
TranscriptomicsA Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe leptospirosis are reported annually, with .10% of these being fatal. Leptospires can survive for weeks in suitably moist conditions b...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2014-03-20 | E-GEOD-53818 | biostudies-arrayexpress
GenomicsSMAD2/3 chromatin immunoprecipitation sequencing (ChIP-seq) in human naïve and primed human pluripotent stem cells
The aim of this experiment was to investigate the role of TGFβ signalling pathway in human pluripotency, through ChIP-seq analysis of its main downstream effector SMAD2/3 in naïve and primed human pluripotent stem cells (hPSCs).
ORGANISM(S): Homo sapiens 
2021-08-13 | E-MTAB-10017 | biostudies-arrayexpress
TranscriptomicsRNA-seq of WTAP knockdown human pluripotent stem cells during the exit from pluripotency induced by Activin/Nodal inhibition
This experiment was designed to monitor the gene expression changes induced by the knockdown of WTAP in human pluripotent stem cells (hPSCs) during the exit from pluripotency induced by the inhibition of Activin/Nodal signalling. hPSCs carrying a tetracycline-inducible short hairpin RNA (shRNA) agai...
ORGANISM(S): Homo sapiens 
2018-01-04 | E-MTAB-5230 | biostudies-arrayexpress
TranscriptomicsExpression data from kidneys of rats with and without glomerulonephritis
We investigated a glomerulonephritis (GN) model in rats induced by nephrotoxic serum (NTS) which contains antibodies against the glomerular basement membrane (GBM). The anti-GBM GN model in rats is widely used since its biochemical and histopathological characteristics are similar to crescentic neph...
ORGANISM(S): Rattus norvegicus 
2015-07-06 | E-GEOD-64265 | biostudies-arrayexpress
TranscriptomicsRNA-seq of definitive endoderm differentiation of human embryonic stem cells in early G1 phase of the cell cycle
The experiment was designed to investigate transcriptional dynamics during definitive endoderm differentiation of human embryonic stem cells (hESCs) in early G1 phase of the cell cycle. For this, the FUCCI system was used to sort hESCs in Early G1 (EG1). Samples were taken at 0h (hESCs), 12h, 24h, 3...
ORGANISM(S): Homo sapiens 
2020-09-07 | E-MTAB-9194 | biostudies-arrayexpress
TranscriptomicsGamma delta T cells isolated from spleen of cold-exposed rats against room-temperature placed control
Wistar male rats were exposed of cold for one day or 14 days. Control group was placed into room temperature. Gamma delta T cells were FACS sorted from spleen.
ORGANISM(S): Rattus norvegicus 
2023-10-30 | E-MTAB-13420 | biostudies-arrayexpress
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