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TranscriptomicsTranscription profiling of mouse fetus exposed to lung and liver of Perfluorooctane sulfonate (PFOS)
Most of the transcriptional changes induced by PFOS in the fetal mouse liver and lung were related to activation of PPARalpha. When compared to the transcript profiles induced by PFOA (Pubmed ID 17681415), few remarkable differences were found other than up-regulation of Cyp3a genes. Because PFOS ...
ORGANISM(S): Mus musculus 
2009-05-16 | E-GEOD-13302 | biostudies-arrayexpress
TranscriptomicsZbtb16 Has a Role in Brown Adipocyte Bioenergetics
Study designed to identify genes that are induced in both BAT and skeletal muscle during acute adaptive thermogenesis in mouse using gene expression microarray. Animal studies were performed under approved UCLA animal research protocols and according to guidelines established in the Guide for Care ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-40486 | biostudies-arrayexpress
TranscriptomicsDrosophila melanogaster developmental timecourse: wild type, eve, ftz
Transcriptional profiling of developmentally staged D. mel. Embryos for three genotypes: wild type, eve3 and ftz11 For additional information, please see Liu et al., 2009. Abstract: We constructed a large-scale functional network model in Drosophila melanogaster built around two key transcription fa...
ORGANISM(S): Drosophila melanogaster 
2008-12-30 | E-GEOD-14086 | biostudies-arrayexpress
TranscriptomicsInterlab microarray comparison Lab D
Microarrays are used to assess the impacts of aquatic contaminants in both laboratory and field studies, which necessitates the validation of the comparability of microarray data generated by different laboratories before this tool is adopted for regulatory toxicology or environmental monitoring. F...
ORGANISM(S): Pimephales promelas 
2016-05-31 | E-GEOD-81352 | biostudies-arrayexpress
GenomicsGenome-wide transcription factor binding and chromatin methylation marks in the G1ME megakaryocytic progenitor model cell line
There are many examples of transcription factor families whose members control gene expression profiles of diverse cell types. However, the mechanism by which closely related factors occupy distinct regulatory elements and impart lineage specificity is largely undefined. Here we demonstrate on a gen...
ORGANISM(S): Mus musculus 
2012-03-05 | E-GEOD-31331 | biostudies-arrayexpress
TranscriptomicsFtz and Eve ChIP data
Genome wide mapping of Ftz and Eve transcription factor binding sites in early Drosophila embryos Ftz has one replicate and dyes swapping Eve has two replicates with one dye swap Mock IPs were used as controls Slides were hybridized with two color samples, but individual channels were uploaded seper...
ORGANISM(S): Drosophila melanogaster 
2010-06-20 | E-GEOD-14289 | biostudies-arrayexpress
TranscriptomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (expression)
Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-50624 | biostudies-arrayexpress
TranscriptomicsA Comparative Study of Genome Wide Transcriptional Profiles of Primary Hepatocyte in In Vitro Cultures
The liver is one of most important organs in our bodies. It performs many essential functions including metabolism, synthesis, secretion, detoxification, and storage. Hepatocytes are the principal cell type in the liver and are involved in multiple liver-specific functions. There have been several e...
ORGANISM(S): Rattus norvegicus 
2010-06-08 | E-GEOD-20659 | biostudies-arrayexpress
TranscriptomicsInterlab microarray comparison Lab C
Microarrays are used to assess the impacts of aquatic contaminants in both laboratory and field studies, which necessitates the validation of the comparability of microarray data generated by different laboratories before this tool is adopted for regulatory toxicology or environmental monitoring. F...
ORGANISM(S): Pimephales promelas 
2016-05-31 | E-GEOD-81348 | biostudies-arrayexpress
TranscriptomicsStrand-specific RNA-seq of nine rat tissues
This experiment is contains rat organism part samples and strand-specific RNA-seq data from experiment E-GEOD-41637 (https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-41637/), which aimed at assessing tissue-specific transcriptome variation across mammals, with chicken used as an outgroup in evo...
ORGANISM(S): Rattus norvegicus 
2012-12-21 | E-MTAB-2800 | biostudies-arrayexpress
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