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TranscriptomicsMolecular characterization of supraclavicular and subcutaneous abdominal adipose tissue samples collected during CE (cold exposure) and TN (thermoneutral) conditions
Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. To gain insight regarding the mechanisms of accelerated lipid metabolism in relation to the cold-a...
ORGANISM(S): Homo sapiens 
2016-05-26 | E-MTAB-4031 | biostudies-arrayexpress
TranscriptomicsRNA messengers translated at the ER membrane
In order to identify what RNA messengers are being translated at the ER membrane, membrane-associated polysomes were separated from free polysomes by subcellular fractionation of WT and delta-egd1/delta-egd2 yeast strains and associated RNA was isolated and then identified by microarray analysis. Se...
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-05 | E-GEOD-45795 | biostudies-arrayexpress
TranscriptomicsIdentification of mRNAs Recruited to Argonaute 2 by Specific microRNAs and Corresponding Changes in Transcript Abundance
This SuperSeries is composed of the following subset Series: GSE11079: mRNAs associated with Ago2: Ago2, Ago2+miR-1, Ago2+miR-124, mock transfected GSE11080: Expression data HEK293T cells transfected with either Ago2, Ago2 + miR-1, Ago2 + miR-124, mock GSE11081: miRNA arrays: Ago2 transfected vs. ...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-11082 | biostudies-arrayexpress
TranscriptomicsPolysomes
Translational profiles of wild type yeast strains were identified by microarray analysis by isolating polysomes using sucrose gradients to recover polysome-associated RNA and comparing polysome-associated RNA vs total RNA Set of arrays that are part of repeated experiments
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-05 | E-GEOD-45797 | biostudies-arrayexpress
TranscriptomicsExpression data HEK293T cells transfected with either Ago2, Ago2 + miR-1, Ago2 + miR-124, mock
HEK293T cell expression data from four conditions: mock transfection, Ago2 transfection, Ago2 & miR-1 transfection, and Ago2 & miR-124 transfection. RNA was isolated directly from 10cm dishes using Trizol reagent and amplified. Set of arrays that are part of repeated experiments Compound Based Treat...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-11080 | biostudies-arrayexpress
TranscriptomicsmRNAs associated with Ago2: Ago2, Ago2+miR-1, Ago2+miR-124, mock transfected
As a core RISC component, Ago2 associates with miRNAs and target mRNAs. To identify these mRNAs, we ran lysate from HEK293T cells over a FLAG resin from 2 conditions: +FLAG-Ago2, +mock transfection. To identify mRNAs associated with specific miRNAs, we ran lysate from HEK293T cells over a FLAG resi...
ORGANISM(S): Homo sapiens 
2008-04-08 | E-GEOD-11079 | biostudies-arrayexpress
TranscriptomicsRNA coimmunoprecipitations
Nascent polypeptides emerging from the ribosome during biogenesis can interact with many chaperones and protein homeostasis factors. The high sensitivity of RNA identification can be used to identify substrates of specific cotranslationally acting chaperones. Protein A-tagged (TAP-tag) chaperones as...
ORGANISM(S): Saccharomyces cerevisiae 
2013-04-05 | E-GEOD-45794 | biostudies-arrayexpress
TranscriptomicsmiRNA arrays: Ago2 transfected vs. Mock, Ago2 IP vs. total RNA
miRNAs were enriched from HEK293T cells using the ambion FLASHPAGE fractionater after mock transfection, Ago2 transfection, and FLAG-Ago2 IP. miRNAs were labeled and hybridized: Ago2 transfected vs. mock transfection and Ago2 transfected vs. Ago2 IPs. Set of arrays that are part of repeated experime...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-11081 | biostudies-arrayexpress
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
BAT transcriptome from control and brown adipocyte-specific Rev-erbα/β double knockout mice housed at thermoneutrality or cold-challenged for 6 hours. Brown adipose tissue (BAT) samples were collected from control and brown adipocyte-specific Rev-erbα/β double knockout mice (Ucp1-Cre; Nr1d1/2 fl/fl)...
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17580 | biostudies-arrayexpress
TranscriptomicsAbiraterone acetate and di-n-butyl phthalate (DBP) response in a human fetal testis xenograft bioassay
The goal of this study was to determine the effects of a well-characterized anti-androgen, abiraterone acetate, and a suspected human anti-androgen, di-n-butyl phthalate (DBP) on the androgenic function of human fetal testis. Human fetal testis was xenografted into the renal subcapsular space of cas...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-49244 | biostudies-arrayexpress
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