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TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
TranscriptomicsPromoter hypermethylation in MLL-r leukemia: biology and therapeutic targeting
MLL-r infant acute lymphoblastic leukemia (ALL) has largely unclear oncogenesis. It has been shown unrelated to copy number change or mutations in the tyrosine kinome. We therefore, explored the possible role of genome wide CpG island hypermethylation in MLL-r infant ALL. We employed the HpaII-ti...
ORGANISM(S): Homo sapiens 
2009-12-29 | E-GEOD-19671 | biostudies-arrayexpress
UnknownImpact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance).
Not available
S-EPMC4268249 | biostudies-literature
TranscriptomicsResponse of multiple genes to a chronic dose of corticosteroids in rat muscles
Synthetic glucocorticoids are used therapeutically for a variety of conditions. Both the efficacy and toxicity of corticosteroids arise from their pharmacologically exaggerated effects on target and non-target tissues. For example, beneficial effects deriving from inhibition of the immune system are...
ORGANISM(S): Rattus norvegicus 
2006-06-19 | E-GEOD-5101 | biostudies-arrayexpress
MetabolomicsMetabolomic signatures discriminate horses with clinical signs of atypical myopathy from healthy co-grazing horses
Atypical myopathy (AM) is a severe rhabdomyolysis syndrome that occurs in grazing horses. Despite the presence of toxins in their blood, all horses from the same pasture are not prone to display clinical signs of AM. The objective of this study was to compare the blood metabolomic profiles of horses...
2021-08-31 | MTBLS2579 | MetaboLights
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility
Environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of adult onset disease, including testis disease and male infertility. The exposure of a gestating female during the period of gonadal sex determination has been shown to promote sperm epimutations, diffe...
ORGANISM(S): Rattus norvegicus 
2012-09-27 | E-GEOD-41173 | biostudies-arrayexpress
TranscriptomicsA role for nuclear factor interleukin-3 (NFIL3), a critical transcriptional repressor, in down-regulation of periovulatory gene expression
The LH surge triggers dramatic transcriptional changes in genes associated with ovulation and luteinization. The present study investigated the spatiotemporal expression of nuclear factor interleukin-3 (NFIL3), a transcriptional regulator of the bZIP transcription factor superfamily, and its potenti...
ORGANISM(S): Rattus norvegicus 
2011-01-20 | E-GEOD-26730 | biostudies-arrayexpress
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