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TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
GenomicsCarroll_ChIP_exo
This experiment validates the ChIP-exo protocol on the Illumina sequencing platform.
ORGANISM(S): Homo sapiens 
2014-01-15 | E-MTAB-1827 | biostudies-arrayexpress
GenomicsHMGB2 in endocrine resistant breast cancer
HMGB2 and ER ChIPseq was investigated in the MCF-7 endocrine sensitive and LY2 endocrine resistant cell lines upon treatment with Tamoxifen.
ORGANISM(S): Homo sapiens 
2014-09-18 | E-MTAB-1865 | biostudies-arrayexpress
GenomicsTLE1 mediates estrogen receptor binding
Estrogen receptor (ER) binds to distal enhancers within the genome and requires additional factors, such as the Forkhead protein FoxA1, for mediating chromatin interactions. We now show that the human Groucho protein, Transducin-like enhancer protein 1 (TLE1), positively assists some ER-chromatin in...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-MTAB-1368 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of six mammals
Homologous vertebrate tissues express a highly conserved set of transcribed genes; paradoxically, expression of tRNAs that are required to translate mRNAs into proteins have been reported to be divergent. To resolve this paradox, we mapped the genome-wide occupancy of pol III in primary tissues iso...
ORGANISM(S): Mus musculus 
2011-07-29 | E-MTAB-424 | biostudies-arrayexpress
GenomicsExploration of the redundancy between FOXA1 and AP2alpha in androgen receptor transcription complex
We performed a comparision of AR binding sites as well as the histone modifications H3K27 acetylation and H3K4 monomethylation in the presence and absence of FoxA1 in the molecular apocrine breast cancer cell line, MDA-MB-453. We also probed AP2alpha binding in asynchronous MDA-MB-453 cells.
ORGANISM(S): Homo sapiens 
2014-04-17 | E-MTAB-1694 | biostudies-arrayexpress
TranscriptomicsER-dependent gene expression in LY2 cell line
ER-dependent gene expression was investigated in the LY2 endocrine resistant cell line by treatment with ICI 182780. Cells were steroid depleted for 3 days prior to treatment with ICI for 6 hours. Four biological replicates were processed and analysed.
ORGANISM(S): Homo sapiens 
2014-09-18 | E-MTAB-1870 | biostudies-arrayexpress
UnknownThe seminal odorant binding protein Obp56g is required for mating plug formation and male fertility in <i>Drosophila melanogaster</i>.
Not available
S-EPMC10834028 | biostudies-literature
UnknownThe seminal odorant binding protein Obp56g is required for mating plug formation and male fertility in <i>Drosophila melanogaster</i>.
Not available
S-EPMC9934574 | biostudies-literature
UnknownMolecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.
Not available
S-EPMC11114609 | biostudies-literature
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