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TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
UnknownIntermediates and the folding of proteins L and G.
Not available
S-EPMC2280051 | biostudies-literature
GenomicsChIP-Seq of human breast cancer cell lines treated with estrogen and tamoxifen to investigate CTCF binding
CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor involved in chromatin looping. Recent evidence has shown a role for CTCF in ER biology. This experiment maps CTCF binding genome-wide in breast cancer cells and shows that CTCF binding does not change with estrogen or tamo...
ORGANISM(S): Homo sapiens 
2011-12-07 | E-MTAB-740 | biostudies-arrayexpress
GenomicsChIP-seq of mouse liver with no antibody to provide input sequences for ChIP experiments on C57BJ/6J mice
This experiment provides chromatin immunoprecipitation input sequences (i.e. no antibody was added during the ChIP protocol), suitable for use as input for ChIP experiments on C57BJ/6J mice.
ORGANISM(S): Mus musculus 
2011-03-01 | E-MTAB-442 | biostudies-arrayexpress
GenomicsChIP-Seq of six mammals tissues: liver, muscle, testes with antibody against RNA polymerase III
Homologous vertebrate tissues express a highly conserved set of transcribed genes; paradoxically, expression of tRNAs that are required to translate mRNAs into proteins have been reported to be divergent. To resolve this paradox, we mapped the genome-wide occupancy of pol III in primary tissues iso...
ORGANISM(S): Homo sapiens 
2011-07-29 | E-MTAB-958 | biostudies-arrayexpress
UnknownParallel loss of sexual reproduction in field populations of a brown alga sheds light on the mechanisms underlying the emergence of asexuality.
Not available
S-EPMC11461277 | biostudies-literature
GenomicsTLE1 mediates estrogen receptor binding
Estrogen receptor (ER) binds to distal enhancers within the genome and requires additional factors, such as the Forkhead protein FoxA1, for mediating chromatin interactions. We now show that the human Groucho protein, Transducin-like enhancer protein 1 (TLE1), positively assists some ER-chromatin in...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-MTAB-1368 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of six mammals
Homologous vertebrate tissues express a highly conserved set of transcribed genes; paradoxically, expression of tRNAs that are required to translate mRNAs into proteins have been reported to be divergent. To resolve this paradox, we mapped the genome-wide occupancy of pol III in primary tissues iso...
ORGANISM(S): Mus musculus 
2011-07-29 | E-MTAB-424 | biostudies-arrayexpress
UnknownDrug Conjugates of Antagonistic R-Spondin 4 Mutant for Simultaneous Targeting of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4/5/6 for Cancer Treatment.
Not available
S-EPMC8713425 | biostudies-literature
UnknownAn assessment of Veterans attitudes and willingness to receiving the COVID-19 vaccine: a mixed methods study.
Not available
S-EPMC8961481 | biostudies-literature
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