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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
ProteomicsAbsence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis
Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-13 | PXD057026 | Pride
Proeomics Mouse Lipidomics Adipose tissue 
TranscriptomicsTranscription profiling of jejunum from chickens with either a high or low natural antibody response which were fed an organic or conventially produced diet
ISA Brown Warren medium heavy layer hens were divergently selected for 25 generations on their primary immune response. Two selection chicken lines were established: chickens with a high natural antibody response (H) and chicken with a low natural antibody response (L). Besides a control line of ran...
ORGANISM(S): Gallus gallus 
2010-03-02 | E-MEXP-1798 | biostudies-arrayexpress
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS382 | MetaboLights
TranscriptomicsDifferential gene expression is not correlated to age-related vascular pathology in aorta and mesenteric artery of Brown Norway and Fischer344xBrown Norway rats
Novel genetic pathways associated with successful and/or unsuccessful vascular aging Customized therapies for vascular disease will require matching the vessel type and genetic background of the patient. Our previous studies showed that progressive age-related vascular pathology is strain specific i...
ORGANISM(S): Rattus norvegicus 
2015-03-02 | E-GEOD-55612 | biostudies-arrayexpress
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS390 | MetaboLights
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS380 | MetaboLights
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
UnknownAbsence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis.
Not available
S-EPMC11730624 | biostudies-literature
TranscriptomicsLongitudinal analysis of developing neointimal vascular proliferation and pulmonary hypertension in rats
6 timepoints: Day 0 (normal controls), progressively developing neointimal vascular proliferation and pulmonary hypertension in vehicle treated animals (Days 14, 21, 28 and 35) and triptolide-treated animals at Day 35. Replicates: 6 for Day 0 (normal) 2 for Daty 14 3 each for Days 21, 28, 35 and Tr...
ORGANISM(S): Rattus norvegicus 
2010-06-05 | E-GEOD-843 | biostudies-arrayexpress
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