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TranscriptomicsTranscription profiling of responses to TNF-alpha, IL-1beta, peptidoglycan or lipopolysaccharide (TLR2/4 agonists) evaluated at 4 hrs in peripheral blood monocytes (PBM) from the patient bearing the IRAK4 Q293X mutation vs PBM from 5 healthy individuals
IL-1R associated kinase-4 (IRAK4) is a key enzyme required for activation of the common Toll-like Receptor (TLR) signaling cascade, which results in the transcription of inflammatory and immunity genes. IRAK-4 deficiency has recently been described as a rare form of innate immunodeficiency. Patien...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-FPMI-7 | biostudies-arrayexpress
UnknownAssessment of Child Lead Exposure in a Philadelphia Community, 2014.
Not available
S-EPMC6916666 | biostudies-literature
TranscriptomicsTranscription profiling of T. brucei in vivo or in vitro samples, with in vitro samples either inclubated at 4oC or not to investiage the influence of culturing condtions on intracellular transport
The vast majority of molecular studies on T. brucei are carried out using in vitro cultures. Recently, whole-genome microarray analysis indicated significant differences between in vivo and in vitro cultures of the malaria parasite Plasmodium falciparum. Therefore, as an additional investigation int...
ORGANISM(S): Trypanosoma brucei 
2008-06-26 | E-MEXP-1540 | biostudies-arrayexpress
UnknownThe genetic breakdown of sporophytic self-incompatibility in Tolpis coronopifolia (Asteraceae).
Not available
S-EPMC5675808 | biostudies-literature
TranscriptomicsTranscription profiling of peripheral blood monocytes from healthy humans and from those with Chronic Granulamatous Disease in response to stimulation with peptidoglycan and lipopolysaccharide
Persons with Chronic Granulomatous Disease, are susceptible to a narrow range of infections resulting from the failure of cells to generate toxic reactive oxygen species (ROS) required for phagocytice oxidative killing of microorganisms. For unknown reasons, many inflammatory conditions (inflammato...
ORGANISM(S): Homo sapiens 
2008-11-05 | E-FPMI-9 | biostudies-arrayexpress
UnknownWhole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
Not available
S-EPMC12418676 | biostudies-literature
UnknownParent Smart: Effects of a Technology-Assisted Intervention for Parents of Adolescents in Residential Substance Use Treatment on Parental Monitoring and Communication
Not available
S-EPMC8791644 | biostudies-literature
UnknownEpigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins.
Not available
S-EPMC9701217 | biostudies-literature
UnknownEnrichable consortia of microbial symbionts degrade macroalgal polysaccharides in Kyphosus fish.
Not available
S-EPMC10705383 | biostudies-literature
UnknownHigh-Resolution Tuning of Iridium(III) 4'-Aryl-terpy Chromophores: A Hammett Parameter-Guided General Methodology for Systematic Property Control through Orbital Decoupling.
Not available
S-EPMC12933883 | biostudies-literature
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