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TranscriptomicsConcomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma
Hibernomas are benign tumors with morphological features resembling brown fat. They consistently display cytogenetic rearrangements, typically translocations, involving chromosome band 11q13. Here we demonstrate that these aberrations are associated with concomitant deletions of AIP and MEN1, tumor ...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-19040 | biostudies-arrayexpress
GenomicsAndrogen receptor cistrome in breast cancer cell line MDA-MB-453 with 5a-dihydrotestosterone (DHT) stimulation
Androgen receptor (AR) is expressed in 60-70% of breast cancers independent of estrogen receptor (ER) expression, however its function in breast cancer is largely unknown. Our study identified the high level of AR in ERâ??/HER2+ breast tumors and andorgen and AR greatly stimulated growth of MDA-MB-4...
ORGANISM(S): Homo sapiens 
2011-07-11 | E-GEOD-28788 | biostudies-arrayexpress
TranscriptomicsChanges of the gene expression profiling induced by fenofibrate
To make investigation of the apoptosis-inducing effect of fenofibrate, the Gene expression profile chip was used to compare the changes between the control group (0M-NM-
ORGANISM(S): Homo sapiens 
2014-03-13 | E-GEOD-49965 | biostudies-arrayexpress
GenomicsChIP-seq study using a cell line model of ER_ AR+ molecular apocrine tumours (AR_FoxA1_molecular_apocrine)
Breast cancer is a heterogeneous disease and several distinct subtypes exist based on differential gene expression patterns. Molecular apocrine tumours were recently identified as an additional subgroup, characterised as oestrogen receptor negative and androgen receptor positive (ER_ AR+), but with ...
ORGANISM(S): Homo sapiens 
2012-02-18 | E-MTAB-986 | biostudies-arrayexpress
GenomicsExploration of the redundancy between FOXA1 and AP2alpha in androgen receptor transcription complex
We performed a comparision of AR binding sites as well as the histone modifications H3K27 acetylation and H3K4 monomethylation in the presence and absence of FoxA1 in the molecular apocrine breast cancer cell line, MDA-MB-453. We also probed AP2alpha binding in asynchronous MDA-MB-453 cells.
ORGANISM(S): Homo sapiens 
2014-04-17 | E-MTAB-1694 | biostudies-arrayexpress
TranscriptomicsDiffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history refle...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-60 | biostudies-arrayexpress
TranscriptomicsSecreted and membrane-associated genes
Large-scale identification of secreted and membrane-associated gene products using DNA microarrays. This study is described more fully in Diehn M et al.(2000) Nat Genet 25:58-62
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-48 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and MDA-MB-231 mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (MDA-MB-231) and cells that represented skeletal compartments (Normal Human (NH) Osteoblast...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29033 | biostudies-arrayexpress
TranscriptomicsHuman splenic marginal zone precursors (MZP) differentiation into marginal zone B cells (MZB)through a Notch2 signalling pathway
RNA microarray profiling analysis was performed on different ex-vivo human splenic B cell subsets (M-^SNaM-oveM-^T, marginal zone precursors or M-^SMZPM-^T, marginal zone B cells orM-^T MZBM-^T, M-^SMTG+CD45+M-^T cells) and on M-^Sp27M-^T cells, corresponding to the fraction of MZP cells that diff...
ORGANISM(S): Homo sapiens 
2014-03-26 | E-MTAB-2244 | biostudies-arrayexpress
GenomicsEffect of FOXA1 over-expression upon AR binding in AR-driven cancers
We performed androgen receptor (AR) ChIP-seq after GFP control or FOXA1 over-expression in two AR driven cancer models; LNCaP prostate cancer cell line and MDA-MB-453 molecular apocrine breast cancer cell line.
ORGANISM(S): Homo sapiens 
2014-01-14 | E-MTAB-1749 | biostudies-arrayexpress
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