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TranscriptomicsER in Liver - 2
Liver transcriptome was analyzed at proestrus (P) and metestrus (M) in liver IGF-1-/- or LID mice. In order to elucidate the mechanism underlying ER control of liver metabolic function, we investigated the genetic programs controlled by the hepatic receptor during the physiological fluctuation of ci...
ORGANISM(S): Mus musculus 
2012-07-04 | E-MEXP-3505 | biostudies-arrayexpress
TranscriptomicsER in liver
In order to elucidate the mechanism underlying ER control of liver metabolic function, we investigated the genetic programs controlled by the hepatic receptor during the physiological fluctuation of circulating E2 in adult female mice. To this aim, we used Affymetrix GeneChip Arrays and compared the...
ORGANISM(S): Mus musculus 
2012-07-04 | E-MEXP-3504 | biostudies-arrayexpress
GenomicsGenome-wide maps of AR binding in prostate cancer cell lines VCaP and VCS2
We report the high-throughput profiling of AR binding in prostate cancer cells. Examination of AR binding in prostate cancer cell lines VCaP and VCS2
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-32345 | biostudies-arrayexpress
GenomicsGenome-wide maps of H3K4me2/3 in prostate cancer cell line LNCaP
We report the high-throughput profiling of histone modifications in prostate cancer cells. By obtaining over 1 billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of prostate cancer cells. we found androgen treatment dismisses a nucleosome o...
ORGANISM(S): Homo sapiens 
2010-03-09 | E-GEOD-20042 | biostudies-arrayexpress
TranscriptomicsAorta- and liver-specific ERalpha binding patterns and gene regulation by estrogen
Estrogen has vascular protective effects in premenopausal women and in women under 60 receiving hormone replacement therapy. However, estrogen also increases risks of breast and uterine cancers and of venous thromboses linked to upregulation of coagulation factors in the liver. In mouse models, the ...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-57804 | biostudies-arrayexpress
TranscriptomicsEstrogen receptor prevents p53-dependent apoptosis in breast cancer
More than two thirds of breast cancers express the estrogen receptor (ER) and depend on estrogen for growth and survival. Therapies targeting ER function including aromatase inhibitors that block the production of estrogens and ER antagonists that alter ER transcriptional activity play a central rol...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-39870 | biostudies-arrayexpress
GenomicsGenome-wide maps of H3K4me2 and DNase I hypersensitivity sites in prostate cancer cell line LNCaP and breast cancer cell line MCF-7.
We report the high-throughput profiling of histone modification and DNase I hypersensitivity sites in prostate cancer and breaset cancer cells. We found that while AR binding is associated with nucleosome depletion, ER binding is not. We showed that a quantitative measure of DNase I hypersensitivity...
ORGANISM(S): Homo sapiens 
2012-03-25 | E-GEOD-33216 | biostudies-arrayexpress
TranscriptomicsLysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity
Lysine Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4), but has coactivator function on some genes through unclear mechanisms. We show that LSD1, interacting with CoREST, associates with and coactivates androgen recep...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-52201 | biostudies-arrayexpress
UnknownSLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer.
Not available
S-EPMC3138634 | biostudies-literature
UnknownHospital costs and factors associated with days alive and at home after surgery (DAH30 ).
Not available
S-EPMC9796479 | biostudies-literature
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