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MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
TranscriptomicsTranscription profiling of rat REF52 cells expressing SV40 T antigens
SV40 transforms cells through the action of two oncoproteins, large T antigen and small t antigen. Small t antigen targets phosphatase PP2A, while large T antigen stimulates cell proliferation and survival by action on multiple proteins, including the tumor suppressors Rb and p53. Large T antigen al...
ORGANISM(S): Rattus norvegicus 
2009-09-12 | E-GEOD-7836 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart left ventricles from 15 week old inbred COP, DA, and F1(COP x DA) offspring with respect to aerobic running capacity (low, high, and intermediate performers respectively)
We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these tw
ORGANISM(S): Rattus norvegicus 
2007-09-13 | E-GEOD-1795 | biostudies-arrayexpress
UnknownRegulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84.
Not available
S-EPMC9292139 | biostudies-literature
MetabolomicsMetabolomic analysis of riboswitch containing E. coli recombinant expression system
In this study we have employed metabolomics approaches to understand the metabolic effects of producing enhanced green fluorescent protein (eGFP) as a recombinant protein in Escherichia coli cells. This metabolic burden analysis was performed against a number of recombinant expression systems and co...
2017-11-16 | MTBLS393 | MetaboLights
TranscriptomicsBuccal epithelial gene expression in smoky and smokeless coal users
Exposure to indoor air pollution generated from the combustion of solid fuels is a major risk factor for a spectrum of cardiovascular and respiratory diseases, including lung cancer. In China’s rural counties of Xuanwei and Fuyuan, lung cancer rates are among the highest in the country. While the ...
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-64277 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of wildtype and two lines of Nrf2 knockout rat livers with or without CDDO-Im treatment
Whole livers were collected from rats treated with or without CDDO-Im. Total RNA was purified using Sepazol-RNA I Super G. Gene expression was measured in livers.
ORGANISM(S): Rattus norvegicus 
2016-08-10 | E-GEOD-77377 | biostudies-arrayexpress
TranscriptomicsEffects of 20 months Dietary Methionine Restriction on Gene Expression in inguinal white adipose tissue of Fischer 344 Rats
Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the inguinal white adipose tissue (IWAT). We analyzed...
ORGANISM(S): Rattus norvegicus 
2013-07-01 | E-GEOD-28599 | biostudies-arrayexpress
UnknownThe impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
Not available
S-EPMC8552693 | biostudies-literature
MetabolomicsSimultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics
Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an opportunity to simultaneously gain deep insights int...
2023-07-03 | MTBLS2746 | MetaboLights
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