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UnknownPhase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma.
Not available
S-EPMC5946714 | biostudies-literature
TranscriptomicsTranscription profiling by array of mouse immortalized embryonic fibroblasts to identify genes regulated by mTORC1
Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a critical regulator of cell growth by integrating multiple signals (nutrients, growth factors, energy and stress) and is frequently deregulated in many types of cancer. We used a robust experimental paradigm involving the combination of two...
ORGANISM(S): Mus musculus 
2011-08-02 | E-GEOD-27982 | biostudies-arrayexpress
TranscriptomicsIdentification of Tfeb-dependent genes downstream of mTORC1 in MEFs
Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a critical regulator of cell growth by integrating multiple signals (nutrients, growth factors, energy and stress) and is frequently deregulated in many types of cancer. We used a robust experimental paradigm involving the combination of two...
ORGANISM(S): Mus musculus 
2011-08-02 | E-GEOD-28021 | biostudies-arrayexpress
TranscriptomicsRenal Cell Carcinoma (RCC) tumorgrafts exhibit similar gene expression profiling to corresponding primary tumors
Primary tumors of Renal Cell Carcinoma (RCC) were implanted orthotopically into mice and their gene expression profiling was compared to their corresponding tumors using Affymetrix Human Genome U133 Plus 2.0 arrays.
ORGANISM(S): Homo sapiens 
2012-06-05 | E-MTAB-1050 | biostudies-arrayexpress
TranscriptomicsRenal Cell Carcinoma (RCC) tumorgrafts exhibit similar DNA copy number alterations to corresponding primary tumors
Primary tumors of Renal Cell Carcinoma (RCC) were implanted orthotopically into mice and their DNA copy number abnormalities were compared to their corresponding tumors using Affymetrix SNP arrays 6.0
ORGANISM(S): Homo sapiens 
2012-06-05 | E-MTAB-1051 | biostudies-arrayexpress
TranscriptomicsDNA Copy-Number Alterations in clear-cell Renal Cell Carcinoma (ccRCC) Tumors and Tumorgrafts for samples deficient in BAP1 or PBRM1
Renal cell carcinoma (RCC) exhibits some unusual features and genes commonly mutated in cancer are rarely mutated in clear-cell RCC (ccRCC), the most common type. The most prevalent genetic alteration in ccRCC is the inactivation of the tumor suppressor gene VHL. Using whole-genome and exome sequenc...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-25540 | biostudies-arrayexpress
TranscriptomicsMolecular Genetic Classification of clear-cell Renal Cell Carcinoma (ccRCC) based on the Gene Expression Profiling of Tumors and Tumorgrafts deficient for BAP1 or PBRM1
Renal cell carcinoma (RCC) exhibits some unusual features and genes commonly mutated in cancer are rarely mutated in clear-cell RCC (ccRCC), the most common type. The most prevalent genetic alteration in ccRCC is the inactivation of the tumor suppressor gene VHL. Using whole-genome and exome sequenc...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-36895 | biostudies-arrayexpress
UnknownPerspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy).
Not available
S-EPMC6042369 | biostudies-literature
TranscriptomicsTranscription profiling of mouse prostate from AKT transgenic or wild type littermate controls treated with RAD001 (MTOR inhibition) or placebo reveals mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways reveals
Transgenic (Probasin driven Myr-AKT)or wild-type littermates were treated with RAD001 or placebo and sacrificed at 12 and 48 hours following the beginning of treatment
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-1413 | biostudies-arrayexpress
UnknownNeoadjuvant SABR for Renal Cell Carcinoma Inferior Vena Cava Tumor Thrombus-Safety Lead-in Results of a Phase 2 Trial.
Not available
S-EPMC8856732 | biostudies-literature
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