Sort   by:  
 Page size 
TranscriptomicsEffect of a dual specificity PI3K/mTOR inhibitor, NVP-BEZ235, on human ovarian cancer cell lines grown in 3D culture
Analysis of the effects of a dual specificity PI3K/mTOR inhibitor on two human ovarian cell lines, OV2008 and MCAS. Results provide insight into the adaptive response to PI3K/mTOR inhibition in matrix attached ovarian cancer cells. The PI3K/mTOR-pathway is the most commonly deregulated pathway in e...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-GEOD-28992 | biostudies-arrayexpress
TranscriptomicsGene expression profiles induced by knockdown and overexpression of p63 variants in MCF-10A mammary epithelial cell line
p63 is critical for epithelial development yet little is known about the transcriptional programmes it regulates. The p63 transactivating (TA) isoforms contain an amino-terminal exon that encodes a p53-like transactivation domain, whereas ΔN-isoforms lack this domain but contain the common DNA bind...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20286 | biostudies-arrayexpress
TranscriptomicsGene profiles induced by overexpression of wild-type and mutant Notch1 variants in MCF10A mammary epithelial cell line
Expression of a constitutively active Notch-1 intracellular domain (NICD) in MCF-10A cells was found to induce two distinct types of 3D structures: large, hyperproliferative structures and small, growth-arrested structures with reduced cell-to-matrix adhesion. These heterogeneous phenotypes reflect...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20285 | biostudies-arrayexpress
TranscriptomicsGene expression profiles induced by shRNA-mediated knockdown of PDEF in MCF7 mammary epithelial cell line
Microarray gene expression analysis was performed in MCF7 cells transduced with a non-specific shRNA or PDEF-targeting shRNA, and both subjected to hormone depletion for 48 hours. Analyses of differentially expressed genes combined with gene ontology revealed a downregulation of cell cycle related-g...
ORGANISM(S): Homo sapiens 
2014-03-29 | E-GEOD-40985 | biostudies-arrayexpress
TranscriptomicsPDEF knockdown and overexpression in mammary epithelial cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-03-29 | E-GEOD-40987 | biostudies-arrayexpress
TranscriptomicsMYC regulation of a "poor prognosis" metastatic cancer cell state
This SuperSeries is composed of the following subset Series: GSE14987: Expression data from ERBB2 over-expression and EGF stimulation in MCF10A cells GSE14988: Expression data from DHT stimulation vs. control in LNCaP cells Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-14990 | biostudies-arrayexpress
Sort   by:  
 Page size