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TranscriptomicsComplex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis [microarray]
In the developing heart, heterotypic transcription factors (TFs) interactions, such as between the T-box TF TBX5 and the homeodomain TF NKX2-5 have been proposed as a mechanism for human congenital heart disease. In order to study the role of each TF during heart formation, embryonic stem (ES) cell-...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-77576 | biostudies-arrayexpress
TranscriptomicsEpigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
Adult-onset diseases can be associated with in utero events, but mechanisms for such temporally distant dysregulation of organ function remain unknown. The polycomb histone methyltransferase, Ezh2, stabilizes transcription by depositing repressive histone marks during development that persist into ...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-30076 | biostudies-arrayexpress
TranscriptomicsThe Polycomb protein Pcgf2/Mel18 regulates mesoderm cell fate-specification of embryonic stem cells through multiple mechanisms
Polycomb complexes are essential regulators of stem cell identity, yet very little is known about their molecular mechanisms during cell differentiation. Pcgf proteins (Pcgf1/2/3/4/5/6) are core subunits of the Polycomb repressive complex 1 (PRC1). It has been recently proposed that specific Pcgf pr...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-67868 | biostudies-arrayexpress
TranscriptomicsChromatin Remodeling Complex Dosage Modulates Transcription Factor Function in Heart Development
Dominant mutations in cardiac transcription factor genes cause human inherited congenital heart defects (CHDs), but their molecular basis is not understood. Transcription factors and Brg1/Brm-associated factor (BAF) chromatin remodeling complex interactions suggest potential mechanisms, but the role...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-26191 | biostudies-arrayexpress
GenomicsComplex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis [Chip-Seq]
Genome-wide occupancy analysis of TBX5, NKX2-5 and GATA4 in differentiating WT, Nkx2-5KO (NKO), Tbx5KO (TKO) and Nkx2-5;Tbx5KO (DKO) cells at the cardiac precursor (CP) and cardiomyocyte (CM) differentiation stages. Analysis of TBX5, NKX2-5 and GATA4 occupancy a and gene expression in WT, Tbx5KO,...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-77548 | biostudies-arrayexpress
TranscriptomicsRNA-seq data: Baf60c homozygous deletion vs. WT at two time points in cardiac differentiation
This project compares Baf60c homozygous deletions to WT at two time points during cardiac differentiation. This data is used in two separate projects: first to assess the role of Baf60c in regulating cardiac gene expression, and second to assess the repeatability of results from different RNA-seq an...
ORGANISM(S): Mus musculus 
2014-08-10 | E-GEOD-59383 | biostudies-arrayexpress
TranscriptomicsComplex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis [RNA-Seq]
Analysis of the changes in gene expression during in vitro cardiomyocyte differentiation due to the lack of Tbx5, Nkx2-5 or both. We performed RNA-seq in WT, Tbx5KO (TKO), Nkx2-5KO (NKO) and Tbx5KO;Nkx2-5KO (DKO) cells at the cardiac precursor (CP) and cardiomyocyte (CM) differentiation stages. Tota...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-77547 | biostudies-arrayexpress
GenomicsComplex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-72223 | biostudies-arrayexpress
TranscriptomicsAnalysis of transcriptome changes in Kmt2d deletion in cardiac mesoderm, anterior heart field precursors and cardiomyocytes
KMT2D is required in the cardiac mesoderm, anterior heart field precursors and cardiomyocytes. Kmt2d deletion in cardiac mesoderm (Mesp1Cre) is embryonic lethal at E10.5 and mutants have hypoplastic hearts; Kmt2d deletion in anterior heart field precursors (Mef2cAHF::Cre) deletion is embryonic letha...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74679 | biostudies-arrayexpress
TranscriptomicsCooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology
Analysis of the roles of Irx3 and Irx5 transcription factors in mouse heart development and postnatal heart function. Results show that show that Irx3 and Irx5 have redundant function in the in the endocardium to regulate atrioventricular canal morphogenesis and outflow tract formation. A postnatal ...
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-38826 | biostudies-arrayexpress
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