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ProteomicsProteins identified by MS on liver lysates immunoprecipitated with an antibody against O-GlcNAcylated proteins (RL2).
Protein O-GlcNAcylation is a fast-cycling and nutrient-sensitive post-translational modification (PTM) involved in several functions, including hepatic metabolsm. The substrate of O-GlcNAcylation is UDP-GlcNAc, the end-product of the hexosamine biosynthesis pathway that is initiated by glutamine. O-...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-06 | PXD024526 | Pride
Liver O-glcnacylation  ogt  oga Mouse 
UnknownMapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration.
Predicting and quantifying phenotypic consequences of genetic variants in rare disorders is a major challenge, particularly pertinent for 'actionable' genes such as thyroid hormone transporter MCT8 (encoded by the X-linked SLC16A2 gene), where loss-of-function (LoF) variants cause a rare neurodevelo...
S-EPMC11904026 | biostudies-literature
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