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ProteomicsRobust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed workflow using data-independent acquisition (mD...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-22 | MSV000090956 | MassIVE
ProteomicsVCF1 is a p97 cofactor promoting recruitment of p97-UFD1-NPL4 to ubiquitylated substrates
The hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ubiquitylated client proteins via multiple cofactors, most of...
ORGANISM(S): Homo sapiens (Human) 
2024-03-14 | PXD043565 | Pride
Ap-ms 
ProteomicsPervasive functional micropeptides in humans encoded by non-canonical open reading frames
Protein-coding regions of the genome continue to expand beyond canonical annotations and remain incompletely understood. Despite recent reports demonstrating important cellular functions played by micropeptides from unannotated open reading frames (ORFs), there exists no systematic method to fully u...
ORGANISM(S): Homo sapiens (Human) 
2020-03-06 | PXD014031 | Pride
Novel orfs Single cell rna analysis Crispr Ribosome sequencing Lcms 
TranscriptomicsTranscription profiling of autumn senescence in populus Leaves
Gene expression profiling in leaves of a free-growing aspen tree (Populus tremula) in Umea in northern Sweden during natural autumn senescence (from August 17 to September 21).
ORGANISM(S): Populus tremula 
2004-03-09 | E-MEXP-93 | biostudies-arrayexpress
ProteomicsGene expression changes in liver upon LCMV Cl13 infection.
2-3 month old female C57Bl/6J mice were intravenously infected with 2x10^6 focus forming units of lymphocytic choriomeningitis virus strain Clone-13. Whole liver tissue was harvested in duplicated from uninfected control mice, uninfected 123d old mice, and from infected at 2, 8, 30, 60, and 123 day...
ORGANISM(S): Mus musculus (Mouse) 
2019-12-02 | PXD011122 | Pride
Lcmv Virus Liver Infection 
TranscriptomicseIF3a in Urinary Bladder Cancer M-bM-^@M-^S in vivo and in vitro insights
The eukaryotic translation initiation factor (eIF) 3a is described in various tumor entities as potential tumor marker involved in development and progression of cancer. eIF3a is the largest subunit of the eIF3 complex, a key functional entity in 80S establishment and translation initiation. We hypo...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-45636 | biostudies-arrayexpress
TranscriptomicsNFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21063 | biostudies-arrayexpress
TranscriptomicsTumor infiltrating IL-33 producing effector-memory CD8+ T cells in resected hepatocellular carcinoma prolong patient survival
Background: IL-33, a cytokine with pleiotropic functions, is elevated in serum of patients with hepatocellular carcinoma (HCC). This study investigated effects of local IL-33 expression in resected HCC on patient survival and on immunological and molecular tumor microenvironment. Methods: Tissue of...
ORGANISM(S): Homo sapiens 
2014-12-08 | E-GEOD-63850 | biostudies-arrayexpress
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