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Gene expression profile at single cell level of breast cell lines HMLE and BT-549
We explored cell heterogeneity by single cell RNA sequencing in normal (HMLE) and cancer (BT-549) mammary cell lines. HMLE is a non-transformed epithelial cell line that possesses only a very small subpopulation of CD44highCD24low cells with mesenchymal and stem-like properties. Given the rarity of ...
ORGANISM(S): Homo sapiens 
2026-06-30 | GSE237726 | GEO
The objective of these experiments is to identify novel direct and indirect targets of miR-150-5p in breast cancer cell lines. The goal is that these will give direction as to what targets or pathways may be contributing to the reduced growth observed in these cell lines upon restoration of miR-150-...
ORGANISM(S): Homo sapiens 
2017-01-01 | GSE87589 | GEO
Polyphyllin D (PD) is the active component from an Asian traditional medicinal herb Paris polyphylla, and has been found to hold significant anticancer activity in vivo or in vitro. However, the mechanism through which PD exerts its anticancer effects in triple-negative breast cancer (TNBC) remains ...
ORGANISM(S): Homo Sapiens 
2023-03-20 | PXD040990 |
Genomics
Transcripts sequencing and MeRIP sequencing of BT-549 and BT-549LMF3
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
Transcriptome analysis for CT mRNA treated BT-549 cells and negative control cells
The goal for this experiment was to analyze how knockdown of homeobox transcription factor Meox1 altered functional and mechanist biology of p53 and PTEN deficient triple negative breast cancer in vitro cell lines of claudin-low BT-549 and basal-like MDA-MB-468.
ORGANISM(S): Homo sapiens 
2020-05-26 | GSE133927 | GEO
two luminal cell lines were added, MCF7 and BT-474 two TNBC cell line were added, MB231 and BT-549 microRNA expression profiles were conpared between the luminal group and the TNBC group
ORGANISM(S): Homo sapiens 
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